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经验公式（希尔记法）:
C19H17Cl3N2S · HNO3
化学文摘社编号:
分子量:
474.79
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
Butoconazole nitrate, United States Pharmacopeia (USP) Reference Standard
InChI key
ZHPWRQIPPNZNML-UHFFFAOYSA-N
SMILES string
ClC1=C(C(Cl)=CC=C1)SC(CCC2=CC=C(Cl)C=C2)CN3C=CN=C3.O[N+]([O-])=O
InChI
1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)
grade
pharmaceutical primary standard
API family
butoconazole
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
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Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
Butoconazole nitrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monograph such as Butoconazole Nitrate Vaginal Cream.
Also, for use with USP monograph such as Butoconazole Nitrate Vaginal Cream.
General description
Butoconazole nitrate (BN) is a imidazole used as an antifungal agent.
Other Notes
Sales restrictions may apply.
Hazard Classifications
Acute Tox. 4 Oral
signalword
Warning
hcodes
pcodes
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
J B Jacobson et al.
Acta obstetricia et gynecologica Scandinavica, 64(3), 241-244 (1985-01-01)
The continuously increasing incidence of vulvovaginal candidiasis necessitated a search for novel therapeutic modalities. Butoconazole nitrate (BN) a new imidazole, has been singled out for clinical studies since, in experimental vaginal candidiasis, it proved more effective than either miconazole nitrate
Meng-meng Jia et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 34(3), 431-436 (2014-06-19)
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of butoconazole in human plasma. Human plasma samples of 0.2 μL were pretreated by a single step protein precipitation procedure and analyzed using a high performance
D Brown et al.
The Journal of reproductive medicine, 44(11), 933-938 (1999-12-10)
To compare the safety and efficacy of a single vaginal dose of a butoconazole nitrate 2% bioadhesive, sustained-release cream* (butoconazole 1-BSR) with a seven-day schedule of miconazole nitrate vaginal cream 2% (miconazole 7). The clinical trial was conducted according to
A Nikolov et al.
Akusherstvo i ginekologiia, 46(9), 23-26 (2008-07-23)
To study the therapeutic application of Gynazol in cases of recurrent vaginal Candida infections during the last trimester of pregnancy. 28 pregnant women in third trimester with recurrent vaginal Candida infection were included in the study. All cases were treated
E Rachev
Akusherstvo i ginekologiia, 46(2), 25-27 (2007-05-02)
to have a personal experience concerning the therapeutic characteristics of the new product GYNAZOL (Gedeon Richter, Ltd)--5 g. vaginal cream for treatment of vulvo-vaginal candidosis (VVC). 31 women in reproductive and climacteric age suffering from acute or chronic VVC. inquiry
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