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Merck
CN

1269200

USP

法莫替丁

United States Pharmacopeia (USP) Reference Standard

别名:

N′-（氨基磺酰基）-3-([2-（二氨基亚甲基氨基）-4-噻唑基]甲硫基)丙脒

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关于此项目

经验公式（希尔记法）:
C8H15N7O2S3
化学文摘社编号:
76824-35-6
分子量:
337.45
NACRES:
NA.24
PubChem Substance ID:
329749830
UNSPSC Code:
41116107
MDL number:
MFCD00079297

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产品名称

法莫替丁, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

SMILES string

N\C(N)=N\c1nc(CSCCC(=N)NS(N)(=O)=O)cs1

InChI key

XUFQPHANEAPEMJ-UHFFFAOYSA-N

biological source

synthetic

grade

pharmaceutical primary standard

agency

USP

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

famotidine

form

powder

packaging

pkg of 125 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white to pale yellow-white

mp

325.4-327.2 °F (163—164°C)

solubility

DMF: freely soluble
acetone: practically insoluble
chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble
ethyl acetate: practically insoluble
glacial acetic acid: freely soluble
methanol: slightly soluble
water: very slightly soluble

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... HRH2(3274)

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相关类别

Biochem/physiol Actions

H2组胺受体拮抗剂；抗溃疡剂。

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Famotidine can be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations by various analytical techniques.(10)

General description

Famotidine is a hydrophilic, cationic, histamine H2 receptor antagonist drug that effectively inhibits gastric acid secretion in humans.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Simultaneous determination of famotidine and flurbiprofen by high performance liquid chromatography
Hanif M, et al.
Tropical Journal of Pharmaceutical Research, 15(3), 605-611 (2016)
Determination of cimetidine, famotidine, and ranitidine hydrochloride in the presence of their sulfoxide derivatives in pure and dosage forms by high-performance thin-layer chromatography and scanning densitometry
Kelani KM, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 85(5), 1015-1020 (2002)
Famotidine
Pharmacopeia, US
United States Pharmacopeia, 39(1)(1-2), 1815-1815 (2020)
Determination of famotidine in acid reduction tablets by HPTLC and videodensitometry of fluorescence quenched zones
Campbell AN and Sherma J
Journal of Liquid Chromatography and Related Technologies, 26(16), 2719-2727 (2003)
Stability indicating method for famotidine in pharmaceuticals using porous graphitic carbon column
Helali N and Monser L
Journal of Separation Science, 31(2) (2008)
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