产品名称
氟比洛芬, United States Pharmacopeia (USP) Reference Standard
InChI
1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
SMILES string
CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
InChI key
SYTBZMRGLBWNTM-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
flurbiprofen
manufacturer/tradename
USP
mp
110-112 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
Gene Information
human ... PTGS1(5742), PTGS2(5743)
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Biochem/physiol Actions
环氧合酶 (COX) 抑制剂；具有抗真菌活性的非甾体抗炎剂。S 对映体可抑制前列腺素的合成，同时具有消炎和镇痛活性，而 R 对映体不会抑制前列腺素的合成，只表现出镇痛活性。
Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
Flurbiprofen USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Flurbiprofen Tablets
- Flurbiprofen Sodium
- Flurbiprofen Sodium Ophthalmic Solution
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Hazard Classifications
Acute Tox. 3 Oral
signalword
Danger
hcodes
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Flurbiprofen Tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 48(3), 1980-1980 (2015)
Flurbiprofen Sodium
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 48(3), 1981-1981 (2020)
Flurbiprofen Sodium Ophthalmic Solution
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 48(3), 1982-1982 (2013)
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