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Merck
CN

1370327

USP

Lorazepam Related Compound A

United States Pharmacopeia (USP) Reference Standard

别名:

3-(Acetyloxy)-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one, (±)-Lorazepam

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关于此项目

经验公式(希尔记法):
C17H12Cl2N2O3
化学文摘社编号:
分子量:
363.19
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
764089
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产品名称

Lorazepam Related Compound A, United States Pharmacopeia (USP) Reference Standard

InChI key

CYDZMDOLVUBPNL-UHFFFAOYSA-N

SMILES string

CC(=O)OC1N=C(c2ccccc2Cl)c3cc(Cl)ccc3NC1=O

InChI

1S/C17H12Cl2N2O3/c1-9(22)24-17-16(23)20-14-7-6-10(18)8-12(14)15(21-17)11-4-2-3-5-13(11)19/h2-8,17H,1H3,(H,20,23)

grade

pharmaceutical primary standard

API family

lorazepam

manufacturer/tradename

USP

format

neat

drug control

kontrollierte Droge in Deutschland
regulated under CDSA - not available from Sigma-Aldrich Canada

application(s)

pharmaceutical (small molecule)

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Lorazepam Related Compound A USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Lorazepam
  • Lorazepam Tablets

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

Exclamation markEnvironment

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Application of ultrafiltration and CD spectroscopy for studying stereoselective binding of racemic ligands.
M Simonyi et al.
Biochemical and biophysical research communications, 109(3), 851-857 (1982-12-15)
Stationary ultrafiltration: a radio-tracer technique for studying stereoselective binding of racemic ligands.
M Simonyi et al.
Biochemical and biophysical research communications, 97(1), 1-7 (1980-11-17)
K Liu et al.
Drug metabolism and disposition: the biological fate of chemicals, 19(3), 609-613 (1991-05-01)
Rates of hydrolysis of racemic and enantiomeric lorazepam 3-acetates (LZA) by esterases in human and rat liver microsomes and rat brain S9 fraction were compared. LZA and its hydrolysis product were analyzed by chiral stationary phase HPLC. When rac-LZA was
Recurrent complex partial status epilepticus associated with tiagabine rechallenge.
R Brouns et al.
Acta neurologica Belgica, 102(1), 19-20 (2002-07-04)
I Fitos et al.
Biochemical pharmacology, 35(2), 263-269 (1986-01-15)
Stereoselective binding of oxazepam, lorazepam, temazepam and methyl lorazepam as well as of their acetates to human serum albumin was investigated by different techniques. The 2'-chlorine and the N(1)-methyl substitution exert opposite effects on the antipodes. Enantiomers of oxazepam acetate

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