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Merck
CN

1414025

USP

氨基蝶呤

United States Pharmacopeia (USP) Reference Standard

别名:

4-氨基-PGA, 4-氨基叶酸, N-[4-[[(2,4-二氨基-6-蝶啶)甲基]氨基]苯甲酰]-L-谷氨酸, （S）-2- {4 - [（2,4-二氨基胍-6-基）甲氨基]苯甲酰氨基}戊二酸

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关于此项目

经验公式（希尔记法）:
C19H20N8O5
CAS Number:
54-62-6
分子量:
440.41
Beilstein:
69045
MDL编号:
MFCD00036692
UNSPSC代码:
41116107
PubChem化学物质编号:
329750411
NACRES:
NA.24

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等级

pharmaceutical primary standard

API类

methotrexate

制造商/商品名称

USP

ε (消光系数)

24,500 at 282 nm in 0.1 M NaOH at 1 M
25,700 at 261 nm in 0.1 M NaOH at 1 M
8,100 at 373 nm in 0.1 M NaOH at 1 M

应用

pharmaceutical (small molecule)

包装形式

neat

SMILES字符串

Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1

InChI

1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1

InChI key

TVZGACDUOSZQKY-LBPRGKRZSA-N

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相关类别

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Methotrexate Related Compound B USP reference standard for use in specified quality tests and assays.

Additionally used to prepare standard, standard stock, system suitability, and system suitability stock solutions for impurity analysis in the given below monographs according to United States Pharmacopeia (USP):
  • Methotrexate
  • Methotrexate Injection
  • Methotrexate for Injection

生化/生理作用

与二氢叶酸还原酶结合并抑制其活性的叶酸拮抗剂。
叶酸拮抗剂。氨基蝶呤是由叶酸转运蛋白运输至细胞内的。在细胞内，它被叶酰聚谷氨酸合酶转化为一种高分子量的聚谷氨酸盐代谢物，该产物又与二氢叶酸还原酶结合并抑制其活性。氨基蝶呤-聚谷氨酸盐经 γ-谷氨酰基水解酶作用发生细胞内降解。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

比甲氨喋呤更有效，但毒性也更强。
Sales restrictions may apply.

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 1 Oral - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Methotrexate for Injection
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(3), 2858-2858 (2020)
Methotrexate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 47(5), 2854-2854 (2022)
Methotrexate Injection
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(4), 2857-2857 (2020)

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