USP

三氟拉嗪盐酸盐

Name: 三氟拉嗪 盐酸盐
Brand: USP

United States Pharmacopeia (USP) Reference Standard

别名:

三氟拉嗪二盐酸盐, 10-[3-(4-甲基哌嗪-1-基)丙基]-2-(三氟甲基)-10H-吩噻嗪二盐酸盐

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经验公式（希尔记法）:

C₂₁H₂₄F₃N₃S · 2HCl

化学文摘社编号:

440-17-5

分子量:

480.42

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329751398

MDL number:

MFCD00012656

Beilstein/REAXYS Number:

3820024

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产品名称

三氟拉嗪盐酸盐, United States Pharmacopeia (USP) Reference Standard

InChI key

BXDAOUXDMHXPDI-UHFFFAOYSA-N

SMILES string

Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1

InChI

1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H

grade

pharmaceutical primary standard

API family

trifluoperazine

manufacturer/tradename

USP

mp

243 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Application

Trifluoperazine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:

Trifluoperazine Hydrochloride Tablets
Trifluoperazine Hydrochloride Injection
Trifluoperazine Oral Solution

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

GHS08,GHS07,GHS09

signalword

Danger

hcodes

H302,H319,H336,H341,H372,H410

pcodes

P201 - P273 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Eyes

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Combinatorial therapy with tamoxifen and trifluoperazine effectively inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades.

Stephanie N Brosius et al.

Journal of neuropathology and experimental neurology, 73(11), 1078-1090 (2014-10-08)

Chemotherapeutic agents effective against malignant peripheral nerve sheath tumors (MPNSTs) are urgently needed. We recently found that tamoxifen potently impedes xenograft growth. In vitro, tamoxifen inhibits MPNST proliferation and survival in an estrogen receptor-independent manner; these effects are phenocopied by

Repurposing the antipsychotic trifluoperazine as an antimetastasis agent.

Ashleigh Pulkoski-Gross et al.

Molecular pharmacology, 87(3), 501-512 (2015-01-02)

Because cancer cell invasion is a critical determinant of metastasis, targeting invasion is a viable approach to prevent metastasis. Utilizing a novel three-dimensional high-throughput invasion assay, we screened a National Cancer Institute compound library and discovered compounds demonstrating inhibitory effects

Evaluation of the in vitro/in vivo potential of five berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) commonly used as herbal supplements to inhibit uridine diphospho-glucuronosyltransferase.

Eu Jin Choi et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 13-19 (2014-07-06)

In this study, we evaluated inhibitory potentials of popularly-consumed berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) as herbal supplements on UGT1A1, UGT1A4, UGT1A6, UGT1A9, and UGT2B7 in vitro. We also investigated the potential herb-drug interaction via UGT1A1 inhibition by

In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug-drug interactions.

Seung Jun Lee et al.

Toxicology letters, 232(2), 458-465 (2014-12-03)

In the present study, we evaluated the inhibitory potentials of finasteride for the major human hepatic UDP-glucuronosyltransferases (UGTs) (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7, and UGT2B15) in vitro using LC-MS/MS by specific marker reactions in human liver microsomes (except for

Evaluation of the in vitro/in vivo drug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition.

Yu Fen Zheng et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 117-127 (2014-03-19)

We evaluated the potential of BST204, a purified dry extract of ginseng, to inhibit or induce human liver cytochrome P450 enzymes (CYPs) and UDP-glucuronosyltransferases (UGTs) in vitro to assess its safety. In vitro drug interactions of four bioactive ginsenosides of

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三氟拉嗪盐酸盐

United States Pharmacopeia (USP) Reference Standard