跳转至内容

CN

Enzymatic hydrolysis of esters containing a tetrazole ring.

Enzymatic hydrolysis of esters containing a tetrazole ring.

Chirality (2014-07-30)

Edyta Łukowska-Chojnacka, Jolanta Mierzejewska

摘要

The lipase-catalyzed enantioselective hydrolysis of acetates containing tetrazole moiety was studied. Among all tested lipases, Novozyme SP 435 allowed to obtain optically active 4-(5-aryl-2H-tetrazol-2yl)butan-2-ol and 1-(5-aryl-2H-tetrazol-2yl)-propan-2-ol and their acetates with the highest optical purities (ee = 95%-99%) and excellent enantioselectivity (E>100). Some of the synthesized tetrazole derivatives were screened for their antifungal activity. Racemic mixtures of 4-[5-(4-chlorophenyl)-2H-tetrazol-2-yl)butan-2-ol as well as pure enantiomers of this compound showed promising antifungal activity against F. sambucinum, F. oxysporum, C. coccodes, and A. niger.

材料

产品编号

品牌

产品描述

Sigma-Aldrich

二甲基亚砜, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

Sigma-Aldrich

二甲基亚砜, ACS reagent, ≥99.9%

Sigma-Aldrich

二甲基亚砜, Molecular Biology

Sigma-Aldrich

二甲基亚砜, suitable for HPLC, ≥99.7%

Sigma-Aldrich

二甲基亚砜, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

Sigma-Aldrich

二甲基亚砜, ReagentPlus^®, ≥99.5%

Sigma-Aldrich

二甲基亚砜, anhydrous, ≥99.9%

Sigma-Aldrich

D -(+)-葡萄糖, ≥99.5% (GC)

Sigma-Aldrich

D -(+)-葡萄糖, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99.5%

Sigma-Aldrich

二甲基亚砜, ≥99.5% (GC), suitable for plant cell culture

Sigma-Aldrich

二甲基亚砜, puriss. p.a., ACS reagent, ≥99.9% (GC)

Sigma-Aldrich

葡萄糖, 97.5-102.0% anhydrous basis, meets EP, BP, JP, USP testing specifications

Sigma-Aldrich

D -(+)-葡萄糖, ≥99.5% (GC), BioXtra

Supelco

葡萄糖, Pharmaceutical Secondary Standard; Certified Reference Material

Sigma-Aldrich

二甲基亚砜, BioUltra, Molecular Biology, ≥99.5% (GC)

USP

右旋糖, United States Pharmacopeia (USP) Reference Standard

Sigma-Aldrich

D -(+)-葡萄糖, BioUltra, anhydrous, ≥99.5% (sum of enantiomers, HPLC)

Sigma-Aldrich

二甲基亚砜, meets EP testing specifications, meets USP testing specifications

Sigma-Aldrich

D -(+)-葡萄糖, ACS reagent

Supelco

D -(+)-葡萄糖, analytical standard

Sigma-Aldrich

二甲基亚砜, PCR Reagent

Sigma-Aldrich

二甲基亚砜, puriss. p.a., dried, ≤0.02% water

Sigma-Aldrich

D -(+)-葡萄糖, suitable for mouse embryo cell culture, ≥99.5% (GC)

Supelco

二甲基亚砜, analytical standard

Sigma-Aldrich

D -(+)-葡萄糖, Hybri-Max^™, powder, BioReagent, suitable for hybridoma

Supelco

二甲基亚砜, for inorganic trace analysis, ≥99.99995% (metals basis)

USP

二甲基亚砜, United States Pharmacopeia (USP) Reference Standard

Sigma-Aldrich

D -(+)-葡萄糖, tested according to Ph. Eur.

Sigma-Aldrich

D-葡萄糖-¹²C₆, ¹⁶O₆, 99.9 atom % ¹⁶O, 99.9 atom % ¹²C

Sigma-Aldrich

3-(Benzyldimethylammonio)propanesulfonate, BioXtra, ≥99.0% (HPCE)