- Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol.
Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol.
Frontiers in pharmacology (2017-08-05)
Xiangmeng Wu, Qinghao Zhang, Jiamei Guo, Yufei Jia, Ziqian Zhang, Manman Zhao, Yakun Yang, Baolian Wang, Jinping Hu, Li Sheng, Yan Li
PMID28769808
摘要
10-Chloromethyl-11-demethyl-12-oxo-calanolide (F18), an analog of calanolide A, is a novel potent nonnucleoside reverse transcriptase inhibitor against HIV-1. Here, we report the metabolic profile and the results of associated biochemical studies of F18