Exogenous proline stimulates type I collagen and HIF-1α expression and the process is attenuated by glutamine in human skin fibroblasts.

Exogenous proline stimulates type I collagen and HIF-1α expression and the process is attenuated by glutamine in human skin fibroblasts.

Molecular and cellular biochemistry (2017-05-21)

Lukasz Szoka, Ewa Karna, Kornelia Hlebowicz-Sarat, Jacek Karaszewski, Jerzy A Palka

摘要

Abundance of proline (Pro) in collagen molecule led us to investigate whether Pro supply affects collagen biosynthesis in human skin fibroblasts. Treatment of the cells with milimolar concentrations (5 and 10 mM) of Pro for 24 and 48 h contributed to increase in α

材料

产品编号

品牌

产品描述

A2066

Sigma-Aldrich

抗肌动蛋白抗体兔抗, affinity isolated antibody, buffered aqueous solution

A4416

Sigma-Aldrich

抗小鼠IgG（全分子）-过氧化物酶山羊抗, affinity isolated antibody, buffered aqueous solution

A9169

Sigma-Aldrich