PHR1962
沙丁胺醇杂质I
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
(1RS)-2-[(1,1-Dimethylethyl)amino]-1-[3-(hydroxymethyl)-4-benzyloxyphenyl]ethanol, 2-tert-Butylamino-1-[3-(hydroxymethyl)-4-benzyloxyphenyl]ethanol
SMILES string
N(C(C)(C)C)CC(O)c1cc(c(cc1)OCc2ccccc2)CO
InChI
1S/C20H27NO3/c1-20(2,3)21-12-18(23)16-9-10-19(17(11-16)13-22)24-14-15-7-5-4-6-8-15/h4-11,18,21-23H,12-14H2,1-3H3
InChI key
ICDQPCBDGAHBGG-UHFFFAOYSA-N
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0000032
API family
salbutamol, albuterol, albuterol
CofA
current certificate can be downloaded
packaging
pkg of 20 mg
application(s)
pharmaceutical
format
neat
storage temp.
2-8°C
Quality Level
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General description
Salbutamol impurity I is a pharmaceutical impurity of salbutamol, belonging to the class of β2-agonists, widely used for the treatment of acute asthma symptoms and exercise-induced asthma in adults and children.
Application
Salbutamol may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations by chromatographic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB2765 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Comparison of isotachophoresis, capillary zone electrophoresis and high-performance liquid chromatography for the determination of salbutamol, terbutaline sulphate and fenoterol hydrobromide in pharmaceutical dosage forms
Ackermans TM, et al.
Journal of Chromatography A, 590(2), 341-353 (1992)
Somsak Sirichai et al.
Talanta, 76(5), 1194-1198 (2008-09-02)
Capillary electrophoresis (CE) with UV detection for the simultaneous and short-time analysis of clenbuterol, salbutamol, procaterol, fenoterol is described and validated. Optimized conditions were found to be a 10 mmoll(-1) borate buffer (pH 10.0), an separation voltage of 19 kV
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