表单
liquid
反应适用性
reaction type: Pegylations
reagent type: cross-linking reagent
官能团
Boc
amine
carboxylic acid
储存温度
−20°C
SMILES字符串
OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
InChI
1S/C17H33NO9/c1-17(2,3)27-16(21)18-4-5-22-6-7-23-8-9-24-10-11-25-12-13-26-14-15(19)20/h4-14H2,1-3H3,(H,18,21)(H,19,20)
InChI key
OLLNIAGWMCSEJB-UHFFFAOYSA-N
应用
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
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法律信息
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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