Merck
CN

1.00419

SAFC

Parteck M 200 (甘露醇)

EMPROVE® ESSENTIAL, Ph. Eur., ChP, JP, USP, E 421

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别名:
D-甘露醇
经验公式(希尔记法):
C6H14O6
CAS号:
分子量:
182.17
MDL编号:
E编号:
E421
EC索引号:
200-711-8

Agency

BP
ChP
JP
Ph. Eur.
USP

质量水平

产品线

EMPROVE® ESSENTIAL

形式

fine powder

自燃温度

410 °C

质量

E 421

粒径

(see specification)

bp

290-295 °C/4 hPa

mp

164-169 °C

溶解性

213 g/L

application(s)

liquid formulation
pharmaceutical
solid formulation

储存温度

2-25°C

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2

InChI key

FBPFZTCFMRRESA-UHFFFAOYSA-N

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一般描述

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid dosage forms. The products in our Parteck® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

应用

Parteck® M excipient achieves excellent compressibility while keeping the API stable throughout your manufacturing process and beyond. Based on directly compressible mannitol, it does not require further processing or high compression forces. The unique and large surface area of Parteck® M excipient enables rapid disintegration and quick release regardless of the dosage. It is well suitable for tableting processesusing direct compression or granulation techniques such as wet granulation androller compaction. Parteck® M is available in different particle sizes.
The specification of the product is part of the Emprove® Material Qualification Dossier and can be found under "General Properties".

特点和优势

  • High compactibility at low compression forces
  • Rapid disintegration and fast dissolution
  • High dilution potential
  • Non-hygroscopic, exceptionally low content of reducing sugars
  • Uniform doses with homogenous distribution

法律信息

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1


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商品

In recent years, mannitol has gained popularity as an excipient in solid dosage formulation due to its beneficial physicochemical properties.

This article describes the advantages of mannitol when used as an excipient in solid drug formulation.

Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.

This article describes the use of excipients to help address API stability issues.

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相关内容

Developing formulations specifically for infants and children is increasingly important. To help you master these challenges effectively, we offer an extensive portfolio of well-established high-quality excipients and APIs for pediatric pharmaceutical formulations that are proven in practice.

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