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PHR1143

赖诺普利

Name: 赖诺普利
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

MK-521, （S）-1- [N2-（1-羧基-3-苯丙基）-赖氨酰脯氨酸二水合物

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关于此项目

经验公式（希尔记法）:

C₂₁H₃₁O₅N₃ · 2H₂O

化学文摘社编号:

83915-83-7

分子量:

441.52

NACRES:

NA.24

PubChem Substance ID:

329823163

UNSPSC Code:

41116107

MDL number:

MFCD01698825

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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. L0702000, traceable to USP 1368609

API family

lisinopril

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

[H]O[H].[H]O[H].NCCCC[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N2CCC[C@H]2C(O)=O

InChI

1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15;;/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29);2*1H2/t16-,17-,18-;;/m0../s1

InChI key

CZRQXSDBMCMPNJ-ZUIPZQNBSA-N

Gene Information

human ... ACE(1636)

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General description

赖诺普利(Lisinopril)是依那普利拉(enalaprilat)的赖氨酸衍生物，属于血管紧张素转换酶(ACE)抑制剂。作为口服药物广泛用于治疗高血压，也可治疗充血性心力衰竭。

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准品提供了一种方便、高性价比的替代方案。

Application

赖诺普利可作为药物参考标准品，用于通过动力学分光光度法测定药物制剂中分析物。

这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

Biochem/physiol Actions

血管紧张素转换酶（ACE）抑制剂。

Analysis Note

这些二级标准品可追溯至USP、EP（PhEur）和BP一级标准品。

Other Notes

分析物的数值在批次间变化很大。

要查看此材料的分析证书(CoA)示例，请在下面的空格中输入LRAB3302。这只是一个示例证书，可能与您收到的批次不符。

该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。

pictograms

GHS08

signalword

Danger

hcodes

H360D,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1A - STOT RE 2

target_organs

Kidney

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Lisinopril

Lancaster GS and Todd AP

Drugs, 35(6), 646-669 (1988)

Determination of lisinopril in pharmaceuticals by a kinetic spectrophotometric method

Cakar M and Popovic G

J. Serb. Chem. Soc., 77(10), 1437-1442 (2012)

Angiotensin converting enzyme inhibitor and HMG-CoA reductase inhibitor as adjunct treatment for persons with HIV infection: a feasibility randomized trial.

Jason V Baker et al.

PloS one, 7(10), e46894-e46894 (2012-10-20)

Treatments that reduce inflammation and cardiovascular disease (CVD) risk among individuals with HIV infection receiving effective antiretroviral therapy (ART) are needed. We conducted a 2 × 2 factorial feasibility study of lisinopril (L) (10 mg daily) vs L-placebo in combination

JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats.

Xinjin Guo et al.

Toxicology and applied pharmacology, 271(2), 285-295 (2013-05-28)

We investigated the effects of JBP485 (an anti-inflammatory dipeptide and a substrate of OAT) on regulation of the expression and function of renal Oat1 and Oat3, which can accelerate the excretion of accumulated uremic toxins (e.g. indoxyl sulfate) in the

Epidermal growth factor receptor inhibitor PKI-166 governs cardiovascular protection without beneficial effects on the kidney in hypertensive 5/6 nephrectomized rats.

Nadir Ulu et al.

The Journal of pharmacology and experimental therapeutics, 345(3), 393-403 (2013-03-27)

Transactivation of epidermal growth factor receptor (EGFR) signaling by G protein-coupled receptors has been implicated in several cardiovascular (CV) conditions, including hypertension, heart failure, and cardiac and vascular hypertrophy. However, the therapeutic potential of EGFR inhibition in these conditions is

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货号	GTIN
PHR1143-1G	04061835237418

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