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PHR1403

酚妥拉明

Name: 酚妥拉明
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

酚妥拉明甲磺酸盐, 2-(N-[m-羟基苯基]-p-甲苯氨基甲基)咪唑啉

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关于此项目

线性分子式:

C₁₇H₁₉N₃O · CH₃SO₃H

化学文摘社编号:

65-28-1

分子量:

377.46

NACRES:

NA.24

PubChem Substance ID:

329823376

UNSPSC Code:

41116107

EC Number:

200-604-6

MDL number:

MFCD00134201

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001127, traceable to USP 1530004

API family

phentolamine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

180-182 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3

InChI

1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)

InChI key

OGIYDFVHFQEFKQ-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

说明

General description

Phentolamine Mesylate belongs to the class of alpha adrenergic antagonist drugs. It is used in the treatment of pheochromocytoma-related hypertension, erectile dysfunction and in the diagnosis of pheochromocytoma and norepinephrine-related dermal necrosis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Phentolamine Mesylate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chemiluminescence technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

α-肾上腺素受体拮抗剂；外周血管舒张剂。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC3261 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Pharmacokinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate

Moore PA, et al.

Anesthesia Progress, 55(2), 40-48 (2008)

Phentolamine mesylate relaxes penile corpus cavernosum tissue by adrenergic and non-adrenergic mechanisms

Traish A, et al.

International Journal of Impotence Research, 10(4), 215-215 (1998)

Long-term safety and efficacy of oral phentolamine mesylate (Vasomax?) in men with mild to moderate erectile dysfunction

Padma-Nathan H, et al.

International Journal of Impotence Research, 14(4), 266-266 (2002)

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全球贸易项目编号

货号	GTIN
PHR1403-1G	04061834416296