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安全信息

安全和法规

D0720000

地塞米松磷酸钠

Name: 地塞米松磷酸钠
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

地塞米松-21-磷酸二钠盐二钠盐

经验公式（希尔记法）:

C₂₂H₂₈FNa₂O₈P

CAS号:

2392-39-4

分子量:

516.40

Beilstein:

6473066

EC 号:

219-243-0

MDL编号:

MFCD00079105

PubChem化学物质编号:

329798630

NACRES:

NA.24

等级

pharmaceutical primary standard

API类

dexamethasone

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

格式

neat

SMILES字符串

[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O

InChI

1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1

InChI key

PLCQGRYPOISRTQ-FCJDYXGNSA-L

基因信息

human ... NR3C1(2908)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Dexamethasone sodium phosphate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

警示用语：

Warning

危险声明

H302 - H361d

预防措施声明

P201 - P301 + P312 + P330 - P308 + P313

危险分类

Acute Tox. 4 Oral - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

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705578-5MG-PW

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Swimming exercise ameliorates depression-like behaviors induced by prenatal exposure to glucocorticoids in rats.

Weina Liu et al.

Neuroscience letters, 524(2), 119-123 (2012-07-21)

Prenatal exposure to glucocorticoids (GCs) leads to affective dysfunction in adulthood, which may be associated with the alterations in hypothalamic-pituitary-adrenal (HPA) axis. Physical exercise has been shown to ameliorate depressive symptoms. The objectives of present study were to investigate whether

Breaking the aggregation of the monoclonal antibody bevacizumab (avastin®) by dexamethasone phosphate: insights from molecular modelling and asymmetrical flow field-flow fractionation.

Marieke Veurink et al.

Pharmaceutical research, 30(4), 1176-1187 (2013-02-16)

To investigate the mechanism behind the aggregation breaking properties of dexamethasone phosphate and related corticosteroids on the IgG1 antibody bevacizumab (Avastin®). An in silico 3D dimer model is developed to identify the bevacizumab-bevacizumab interface, and different corticosteroids are docked onto

Bupleurum chinense DC polysaccharides attenuates lipopolysaccharide-induced acute lung injury in mice.

Jun-yun Xie et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(2), 130-137 (2011-11-25)

Bupleurum chinense DC had hepato-protective, anti-inflammatory, antipyretic, analgesic, and immunomodulatory effect in traditional Chinese medicine. This study was to determine whether the crude polysaccharides isolated from the roots of Bupleurum chinense DC (BCPs) attenuated lipopolysaccharide (LPS)-induced acute lung injury in

Effect of menthol on ocular drug delivery.

Xiaolin Xu et al.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 249(10), 1503-1510 (2011-05-21)

To assess how safe and effective it is to use menthol as a permeability enhancer in ophthalmic drug delivery systems. In this study, the effect of menthol on permeability of dexamethasone disodium phosphate in the cornea and sclera was investigated

Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives.

Martin Gräber et al.

ACS chemical biology, 6(10), 1008-1014 (2011-07-30)

Phosphorylation-dependent protein binding domains are crucially important for intracellular signaling pathways and thus highly relevant targets in chemical biology. By screening of chemical libraries against 12 structurally diverse phosphorylation-dependent protein binding domains, we have identified fosfosal and dexamethasone-21-phosphate as selective

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地塞米松磷酸钠

European Pharmacopoeia (EP) Reference Standard

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等级

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应用

格式

SMILES字符串

InChI

InChI key

基因信息

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说明

一般描述

应用

包装

其他说明

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警示用语：

危险声明

预防措施声明

危险分类

储存分类代码

WGK

闪点(°F)

闪点(°C)

法规信息

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