PHR1053
硫酸舒喘灵
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
Albuterol Sulfate, α-([t-Butylamino]methyl)-4-hydroxy-m-xylene-α,α′-diol, Salbutamol hemisulfate salt
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关于此项目
经验公式（希尔记法）:
C26H44N2O10S
分子量:
576.70
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
256-916-8
NACRES:
NA.24
SMILES string
[S](=O)(=O)(O)O.N(C(C)(C)C)CC(O)c2cc(c(cc2)O)CO.N(C(C)(C)C)CC(O)c1cc(c(cc1)O)CO
InChI key
BNPSSFBOAGDEEL-UHFFFAOYSA-N
InChI
1S/2C13H21NO3.H2O4S/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h2*4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. S0150000, traceable to USP 1012633
API family
albuterol, salbutamol
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... ADRB2(154)
General description
Albuterol sulfate is a β2 adrenergic agonist and a bronchodilating agent, which is used in the treatment of asthma.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
Albuterol sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by ultra-performance liquid chromatographic method with ultraviolet detection (UPLC-UV).
Albuterol sulfate may be used as a reference standard in determining the concentration of albuterol sulfate present in inhalers using reversed-phase high performance liquid chromatography (RP-HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7128 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Repr. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Comparison of conventional HPLC with UPLC method for determination of albuterol sulfate and it?s impurities in pharmaceutical formulation.
Dalvi PN, et al.
Orient. J. Chem., 24(2), 537-544 (2008)
Determination of albuterol sulfate and its related substances in albuterol sulfate inhalation solution, 0.5% by RP-HPLC
Erram.VS, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(4), 864-874 (2006)
Supercritical and near-critical carbon dioxide assisted low-temperature bubble drying
Sievers.ER, et al.
Industrial & Engineering Chemistry Research, 39(12), 4831-4836 (2000)
B Padhukasahasram et al.
The pharmacogenomics journal, 14(4), 365-371 (2014-01-15)
Inhaled short-acting beta-agonist (SABA) medication is commonly used in asthma patients to rapidly reverse airway obstruction and improve acute symptoms. We performed a genome-wide association study of SABA medication response using gene-based association tests. A linear mixed model approach was
Clinical Practice. Mild asthma.
Elisabeth H Bel
The New England journal of medicine, 369(6), 549-557 (2013-08-09)
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