PHR1094
非那西丁
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
N-(4-乙氧苯基)乙酰胺, 乙酰乙氧基苯胺, 乙酰对氨基苯乙醚, 对乙氧基乙酰苯胺, 对乙酰乙氧基苯胺
等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to USP 1514008
API类
phenacetin
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
~Approximately 135 °C
133-136 °C (lit.)
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
CCOc1ccc(NC(C)=O)cc1
InChI
1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)
InChI key
CPJSUEIXXCENMM-UHFFFAOYSA-N
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一般描述
Phenacetin is a mild analgesic drug effective for the treatment of mild to moderate pain. Its analgesic property is comparable to that of aspirin.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
Phenacetin may be used as a calibration standard for the development of a test for the evaluation of phenacetin by thermal analyzes methods.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
生化/生理作用
CYP1A2 和 CYP2D6 的底物。
分析说明
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
其他说明
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC4010 in the slot below. This is an example certificate only and may not be the lot that you receive.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Carc. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
涉药品监管产品
此项目有
Purity and heat of fusion data for environmental standards as determined by differential scanning calorimetry
Donnelly JR, et al.
Thermochimica Acta, 167(2), 155-187 (1990)
Paracetamol and phenacetin
Clissold SP
Drugs, 32(4), 46-59 (1986)
Broad range purity analysis by melting point depression using a singular feature common to all DSC purity scans
Gustin GM
Thermochimica Acta, 39(2), 81-93 (1980)
L F Prescott
British journal of clinical pharmacology, 10 Suppl 2, 291S-298S (1980-10-01)
1 The rate of absorption of oral paracetamol depends on the rate of gastric emptying and is usually rapid and complete. The mean systemic availability is about 75%. 2 Paracetamol is extensively metabolized and the plasma half-life is 1.5-2.5 hours.
[Phenacetin abuse I. Occurrence, per capita consumption and costs of treatment].
M J Mihatsch et al.
Schweizerische medizinische Wochenschrift, 110(4), 108-115 (1980-01-28)
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