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CN

PHR1129

丁卡因 盐酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯, 丁卡因 盐酸盐

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关于此项目

经验公式（希尔记法）:
C15H24N2O2 · HCl
化学文摘社编号:
136-47-0
分子量:
300.82
NACRES:
NA.24
PubChem Substance ID:
329823150
UNSPSC Code:
41116107
MDL number:
MFCD00038912

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产品名称

丁卡因 盐酸盐, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H

SMILES string

Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C

InChI key

PPWHTZKZQNXVAE-UHFFFAOYSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. T0500000
traceable to USP 1650006

API family

tetracaine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

眼用局部麻醉药；用于脊髓麻醉
Tetracaine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

阻断 Ca2+ 从肌浆网的电压敏感性释放。

General description

Tetracaine hydrochloride is a local anesthetic drug and an ester derivative of p-amino benzoic acid. It acts by interfering with the entry of sodium ions into nerve cells and is one of the commonly used topical anesthetics.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7150 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - STOT SE 3

target_organs

Central nervous system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Tetracaine hydrochloride
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3742-3743 (2017)
14 - Local Anesthetics
Pharmacology and Therapeutics for Dentistry, 206-220 (2017)
Determination of Two Components in Tetracaine Hydrochloride Eye Drops by HPLC [J]
Yahong L, et al.
Chinese Pharmaceutical Journal, 14(2), 381-386 (2009)
Local Anesthetic Pharmacology
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 206-220 (2017)
Determination of cetylpyridinium chloride and tetracaine hydrochloride in buccal tablets by RP-HPLC
Wang J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 32(2), 381-386 (2003)
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