PHR1129
丁卡因 盐酸盐
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯, 丁卡因 盐酸盐
等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to Ph. Eur. T0500000
traceable to USP 1650006
API类
tetracaine
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-30°C
SMILES字符串
Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InChI
1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H
InChI key
PPWHTZKZQNXVAE-UHFFFAOYSA-N
基因信息
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相关类别
一般描述
Tetracaine hydrochloride is a local anesthetic drug and an ester derivative of p-amino benzoic acid. It acts by interfering with the entry of sodium ions into nerve cells and is one of the commonly used topical anesthetics.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
眼用局部麻醉药；用于脊髓麻醉
Tetracaine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
生化/生理作用
阻断 Ca2+ 从肌浆网的电压敏感性释放。
分析说明
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
其他说明
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7150 in the slot below. This is an example certificate only and may not be the lot that you receive.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Local Anesthetic Pharmacology
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 206-220 (2017)
Determination of Two Components in Tetracaine Hydrochloride Eye Drops by HPLC [J]
Yahong L, et al.
Chinese Pharmaceutical Journal, 14(2), 381-386 (2009)
Tetracaine hydrochloride
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3742-3743 (2017)
14 - Local Anesthetics
Pharmacology and Therapeutics for Dentistry, 206-220 (2017)
Tetracaine hydrochloride
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 4106-4106 (2018)
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