PHR1129
丁卡因 盐酸盐
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯, 丁卡因 盐酸盐
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关于此项目
经验公式（希尔记法）:
C15H24N2O2 · HCl
化学文摘社编号:
分子量:
300.82
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H
SMILES string
Cl.CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InChI key
PPWHTZKZQNXVAE-UHFFFAOYSA-N
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. T0500000, traceable to USP 1650006
API family
tetracaine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
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General description
Tetracaine hydrochloride is a local anesthetic drug and an ester derivative of p-amino benzoic acid. It acts by interfering with the entry of sodium ions into nerve cells and is one of the commonly used topical anesthetics.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
眼用局部麻醉药；用于脊髓麻醉
Tetracaine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
阻断 Ca2+ 从肌浆网的电压敏感性释放。
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7150 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Tetracaine hydrochloride
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 4106-4106 (2018)
Local Anesthetic Pharmacology
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 206-220 (2017)
Determination of cetylpyridinium chloride and tetracaine hydrochloride in buccal tablets by RP-HPLC
Wang J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 32(2), 381-386 (2003)
Tetracaine hydrochloride
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3742-3743 (2017)
Determination of Two Components in Tetracaine Hydrochloride Eye Drops by HPLC [J]
Yahong L, et al.
Chinese Pharmaceutical Journal, 14(2), 381-386 (2009)
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