PHR1182
罂粟碱 盐酸盐
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride
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关于此项目
经验公式（希尔记法）:
C20H21NO4 · HCl
化学文摘社编号:
分子量:
375.85
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-502-1
Beilstein/REAXYS Number:
3921435
MDL number:
InChI
1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H
InChI key
UOTMYNBWXDUBNX-UHFFFAOYSA-N
SMILES string
COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. P0270000, traceable to USP 1496008
API family
papaverine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
food and beverages
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
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General description
Papaverine hydrochloride is the hydrochloride salt of an opiate derivative called papaverine, a benzylisoquinoline compound. It has been found to relax smooth muscles of blood vessels and is used in the management of occlusivity and spasticity of pulmonary, coronary and peripheral arteries.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
Papaverine hydrochloride is used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9001 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Simultaneous determination of dipyrone and papaverine in pharmaceutical formulation using PLS regression and UV spectrophotometry
do Nascimento AP, et al.
Analytical Letters, 40(5), 975-986 (2007)
The effect of intravenous papaverine hydrochloride on the cerebral circulation
Jayne H W, et al
The Journal of Clinical Investigation, 31(1), 111-114 (1952)
Simultaneous assay of ephedrine hydrochloride, theophylline, papaverine hydrochloride and hydroxyzine hydrochloride in tablets using RP-LC
Boberi B, et al.
Journal of Pharmaceutical and Biomedical Analysis, 21(1), 15-22 (1999)
Spectrophotometric determination of meclozine HCl and papaverine HCl in their pharmaceutical formulations
Abdel-Ghani NT, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(2), 373-378 (2002)
Alaa El-Gindy
Farmaco (Societa chimica italiana : 1989), 60(9), 745-753 (2005-07-19)
Three methods are developed for the simultaneous determination of diprophylline (DP), phenobarbitone (PH) and papaverine hydrochloride (PP). The chromatographic method depends on a high performance liquid chromatographic (HPLC) separation on a reversed-phase C18 column with a mobile phase consisting of
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