PHR1216
癸二酸二丁酯
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
癸二酸二正丁酯, 皮脂酸二丁酯
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线性分子式:
[-(CH2)4CO2(CH2)3CH3]2
化学文摘社编号:
分子量:
314.46
Beilstein:
1798308
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
traceable to USP 1187091
API类
dibutyl sebacate
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
折射率
n20/D 1.441 (lit.)
沸点
178-179 °C/3 mmHg (lit.)
密度
0.936 g/mL at 25 °C (lit.)
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-30°C
SMILES字符串
CCCCOC(=O)CCCCCCCCC(=O)OCCCC
InChI
1S/C18H34O4/c1-3-5-15-21-17(19)13-11-9-7-8-10-12-14-18(20)22-16-6-4-2/h3-16H2,1-2H3
InChI key
PYGXAGIECVVIOZ-UHFFFAOYSA-N
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一般描述
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Dibutyl sebacate is a commonly used plasticizer, which can be synthesized by the reaction of butyl alcohol and sebacyl chloride or by the distillation of sebacic acid with butyl alcohol in the presence of concentrated hydrochloric acid in benzene solution.
应用
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
分析说明
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
其他说明
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9029 in the slot below. This is an example certificate only and may not be the lot that you receive.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
366.8 °F - open cup
闪点(°C)
186 °C - open cup
Burdock AG et al.
Encyclopedia of Food & Color Additives, 1 (1997)
T Quinten et al.
Drug development and industrial pharmacy, 37(2), 149-159 (2010-07-10)
It was the aim of the present study to develop sustained-release matrix tablets by means of injection molding of ethylcellulose (EC) and polyethylene oxide (PEO) mixtures and to evaluate the influence of process temperature, matrix composition, and viscosity grade of
T Quinten et al.
Journal of pharmaceutical sciences, 100(7), 2858-2870 (2011-01-22)
Sustained-release matrix tablets were developed by injection moulding using metoprolol tartrate (MPT) and ethylcellulose (EC) as sustained-release agent. Dibutyl sebacate was selected as plasticiser. The influence of matrix composition, plasticiser concentration, and drug load on drug release was evaluated. The
D Stark et al.
Biotechnology and bioengineering, 83(4), 376-385 (2003-06-12)
A novel in situ product removal (ISPR) method that uses microcapsules to extract inhibitory products from the reaction suspension is introduced into fermentation technology. More specifically, L-phenylalanine (L-Phe) was transformed by Saccharomyces cerevisiae to 2-phenylethanol (PEA), which is inhibitory toward
Maarit Tarvainen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 19(5), 363-371 (2003-08-09)
The aim of this study was to investigate the ability of n-alkenyl succinic anhydrides (n-ASAs) to improve the film-forming characteristics of a novel coating polymer, potato starch acetate degree of substitution 2.8 (SA). n-ASAs were also applied to improve the
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