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Merck
CN

PHR1256

硫酸阿巴卡韦

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

硫酸阿巴卡韦 硫酸酯

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关于此项目

经验公式（希尔记法）:
C28H36N12O2 · H2SO4
化学文摘社编号:
188062-50-2
分子量:
670.74
UNSPSC Code:
41116107
NACRES:
NA.24

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产品名称

硫酸阿巴卡韦, Pharmaceutical Secondary Standard; Certified Reference Material

SMILES string

[S](=O)(=O)([O-])[O-].[n+]6(c7nc(nc(c7[nH]c6)NC8CC8)N)[C@@H]5C[C@@H](C=C5)CO.[n+]2(c3nc(nc(c3[nH]c2)NC4CC4)N)[C@@H]1C[C@@H](C=C1)CO

InChI

1S/2C14H18N6O.H2O4S/c2*15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21;1-5(2,3)4/h2*1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19);(H2,1,2,3,4)/t2*8-,10+;/m11./s1

InChI key

WMHSRBZIJNQHKT-FFKFEZPRSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001561
traceable to USP 1000408

API family

abacavir

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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相关类别

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Application

Abacavir sulfate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-peformance liquid chromatography technique and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Abacavir sulfate belongs to the class of human immunodeficiency virus (HIV) medicines called nucleoside reverse transcriptase inhibitors, with antiretroviral activity against HIV.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3642 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Determination of abacavir, lamivudine and zidovudine in pharmaceutical tablets, human serum and in drug dissolution studies by HPLC
Savaser A, et al.
Chromatographia, 65(5-6), 259-265 (2007)
Spectrophotometric methods for the determination of abacavir sulphate in pharmaceutical preparations
Srihari G
Global Journal of Pharmacology, 5(3), 172-175 (2011)

商品

LC-MS Analysis of Serum for a Wide Analyte Range Using a Novel HLB SPE Phase

Analysis of 20 pharmaceutical compounds in calf serum using Supel™ Swift HLB SPE cartridge for cleanup and LC-MS determination and another commercially available HLB cartridge for comparison.

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