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Merck
CN

PHR1282

硫唑嘌呤

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

6-[(1-甲基-4-硝基-1H-咪唑-5-基)硫代]-1H-嘌呤

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经验公式（希尔记法）:
C9H7N7O2S
化学文摘社编号:
446-86-6
分子量:
277.26
NACRES:
NA.24
PubChem Substance ID:
329823278
UNSPSC Code:
41116107
EC Number:
207-175-4
MDL number:
MFCD00069203

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产品名称

硫唑嘌呤, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

LMEKQMALGUDUQG-UHFFFAOYSA-N

InChI

1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)

SMILES string

Cn1cnc(c1Sc2ncnc3[nH]cnc23)[N+]([O-])=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. A1500000
traceable to USP 1046001

API family

azathioprine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... PPAT(5471)

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相关类别

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Azathioprine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using 1H NMR spectroscopy and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Azathioprine is a potentially useful antileukaemic drug, with immunosuppressive action, which is administered orally or by I.V route. It is widely used to treat a variety of auto-immune disorders and also has a marked effect on T-lymphocytes and suppresses cell mediated immunity.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0017 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Quantitative determination of azathioprine in tablets by 1H NMR spectroscopy
Goger GN, et al.
Journal of Pharmaceutical and Biomedical Analysis, 21(3), 685-690 (2000)
Spectrophotometric determination of azathioprine in bulk and pharmaceutical dosage forms
Bhaskar M, et al.
International Journal of ChemTech Research, 2(1), 376-378 (2010)
Laurent Peyrin-Biroulet et al.
Gut, 63(1), 88-95 (2013-08-27)
The Crohn's Disease Activity Index (CDAI) has been criticised due to heavy weighting on subjective clinical symptoms. C-reactive protein (CRP) and endoscopic lesions are objective measures of inflammation. We investigated the relationships between clinical disease activity, CRP normalisation and mucosal
Joanna Kitley et al.
Journal of neurology, neurosurgery, and psychiatry, 84(8), 918-921 (2013-03-08)
Neuromyelitis optica (NMO) is a severe autoimmune inflammatory disorder associated with considerable relapse-related disability. Immunosuppression is the mainstay of treatment but many patients do not tolerate first-line immunosuppressive agents, or experience ongoing relapses. To evaluate the effectiveness and tolerability of
Systemic therapies for severe atopic dermatitis in children and adults.
Carsten Flohr et al.
The Journal of allergy and clinical immunology, 132(3), 774-774 (2013-09-03)
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