PHR1283
头孢克洛
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
Cefaclor monohydrate
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关于此项目
经验公式（希尔记法）:
C15H14ClN3O4S · H2O
化学文摘社编号:
分子量:
385.82
UNSPSC Code:
41116107
EC Number:
258-909-5
NACRES:
NA.24
SMILES string
S1[C@H]2N(C(=C(C1)Cl)C(=O)O)C(=O)[C@H]2NC(=O)[C@H](N)c3ccccc3.O
InChI key
WKJGTOYAEQDNIA-IOOZKYRYSA-N
InChI
1S/C15H14ClN3O4S.H2O/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7;/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23);1H2/t9-,10-,14-;/m1./s1
grade
certified reference material, pharmaceutical secondary standard
agency
USP 1096906, traceable to Ph. Eur. C0630000
API family
cefaclor
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cefaclor belongs to the class of second generation semi-synthetic cephalosporin antibiotic drugs that is normally administered orally. With its broad-spectrum antibacterial action, cefaclor is effective against several gram-positive as well as gram-negative bacteria.
Cefaclor belongs to the class of second generation semi-synthetic cephalosporin antibiotic drugs that is normally administered orally. With its broad-spectrum antibacterial action, cefaclor is effective against several gram-positive as well as gram-negative bacteria.
Application
Cefaclor may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological samples by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3323 in the slot below. This is an example certificate only and may not be the lot that you receive.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Simultaneous determination of cefpirome, cefaclor, ceftazidime, and cephradine in pharmaceutical formulations by reversed phase HPLC
Nawaz M, et al.
Acta Chromatographica , 23(2), 205-213 (2011)
The use of a monolithic column to improve the simultaneous determination of four cephalosporin antibiotics in pharmaceuticals and body fluids by HPLC after solid phase extraction-a comparison with a conventional reversed-phase silica-based column
Samanidou VF, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 809(1), 175-182 (2004)
Determination of cefaclor in human plasma by a sensitive and specific liquid chromatographic-tandem mass spectrometric method
Chen X, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 784(1), 17-24 (2003)
Rapid and sensitive high-performance liquid chromatographic determination of four cephalosporin antibiotics in pharmaceuticals and body fluids
Samanidou VF, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 788(1), 147-158 (2003)
Determination of process-related impurities and degradation products in cefaclor by high-performance liquid chromatography
Lorenz LJ, et al.
Journal of Chromatographic Science, 30(6), 211-216 (1992)
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