PHR1290
硝苯地平
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
硝苯地平, 1,4-二氢-2,6-二甲基-4-(2-硝基苯基)-3,5-吡啶二甲酸二甲酯
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关于此项目
经验公式（希尔记法）:
C17H18N2O6
化学文摘社编号:
分子量:
346.33
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
244-598-3
MDL number:
产品名称
硝苯地平, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
HYIMSNHJOBLJNT-UHFFFAOYSA-N
InChI
1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
SMILES string
COC(=O)C1=C(C)NC(C)=C(C1c2ccccc2[N+]([O-])=O)C(=O)OC
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. N0750000
traceable to USP 1463508
API family
nifedipine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)
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Analysis Note
这些二级标准品可追溯至USP、EP（PhEur）和BP一级标准品。
Application
硝苯地平可用作药物参考标准品，用于通过分光光度法和色谱技术测定药物制剂和血浆样品中的分析物。
这些二级标准品是合格的认证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。
General description
用于质量控制的药物二级标准，为制药实验室和制造商提供一种方便且性价比高的替代内部工作标准的制备方法。
硝苯地平属于钙通道拮抗剂药物，被广泛用作抗高血压药物和抗心绞痛剂。它也可以用作冠状血管扩张剂。
硝苯地平属于钙通道拮抗剂药物，被广泛用作抗高血压药物和抗心绞痛剂。它也可以用作冠状血管扩张剂。
Other Notes
想要查看本品的检验报告示例，请在下框中输入LRAA0488。这只是一个示例证书，可能与您收到的批次不符。
该认证标准物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在检验报告上找到。
Determination of nifedipine in human plasma by high-performance liquid chromatography with electrochemical detection
Suzuki H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 341(1), 341-347 (1985)
New spectrophotometric methods for the determination of nifedipine in pharmaceutical formulations
Rahman N and Azmi SNH
Acta Biochimica Polonica, 52(4), 915-915 (2005)
A F el Walily
Journal of pharmaceutical and biomedical analysis, 16(1), 21-30 (1998-02-03)
Three methods are described for the simultaneous determination of nifedipine and acebutolol hydrochloride in combined pharmaceutical tablets. The first method depends on first-derivative ultraviolet spectrophotometry, with peak-to-base and zero-crossing measurements methods. The first derivative amplitudes at 400 and 352 nm
Norio Taira
Drugs, 66 Spec No 1, 1-3 (2008-01-19)
Nifedipine was synthesized by Bayer Germany in 1966 and considered for clinical use as a coronary vasodilator in patients with angina pectoris. Japanese investigators played a great part in the pre-clinical and clinical development of nifedipine. Professor Hashimoto demonstrated that
Corey B Toal et al.
Blood pressure, 21 Suppl 1, 3-10 (2012-07-06)
Calcium-channel blockers (CCBs) constitute a diverse group of compounds but are often referred to as a single homogeneous class of drug and the clinical responses indiscriminately summarized. Even within the dihydropyridine subgroup, there are significant differences in formulations, pharmacokinetics, durations
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