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PHR1302

盐酸普莫卡因

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

普莫卡因 盐酸盐

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关于此项目

经验公式(希尔记法):
C17H27NO3 · HCl
化学文摘社编号:
分子量:
329.86
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
211-293-1
MDL number:
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Quality Level

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1554002

API family

pramoxine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.CCCCOc1ccc(OCCCN2CCOCC2)cc1

InChI

1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H

InChI key

SYCBXBCPLUFJID-UHFFFAOYSA-N

General description

Pramoxine hydrochloride is a hydrochloride salt of pramoxine, widely used for its local anesthetic and antipruritic properties. Its ability to relieve itching arises from its stabilizing effect on the neuronal membranes of the nerve terminals. It is widely used as a pain medicine for various conditions such as skin irritations, rashes, hemorrhoids, and minor wound care.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Pramoxine hydrochloride may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

用于皮肤或粘膜的局部麻醉

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA1519 in the slot below. This is an example certificate only and may not be the lot that you receive.


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pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable



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Efficacy and onset of action of hydrocortisone acetate 2.5% and pramoxine hydrochloride 1% lotion for the management of pruritus: results of a pilot study
Kircik LH
The Journal of Clinical and Aesthetic Dermatology, 4(2), 48-48 (2011)
Simultaneous determination of pramoxine HCl and benzalkonium chloride in wound care solutions by HPLC
Tavlarakis P,et al
Analytical Methods : Advancing Methods and Applications, 2(6), 722-727 (2010)
Comparative study of two different chromatographic approaches for quantitation of hydrocortisone acetate and pramoxine hydrochloride in presence of their impurities
Ibrahim F, et al.
Journal of food and drug analysis, 26(3), 1160-1170 (2018)



全球贸易项目编号

货号GTIN
PHR1302-1G04061834415800