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Merck
CN

PHR1390

兰索拉唑

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

兰索拉唑

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关于此项目

经验公式（希尔记法）:
C16H14F3N3O2S
化学文摘社编号:
103577-45-3
分子量:
369.36
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00866873

主要文件

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产品名称

兰索拉唑, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)

SMILES string

Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F

InChI key

MJIHNNLFOKEZEW-UHFFFAOYSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000773
traceable to USP 1356916

API family

lansoprazole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... ATP4A(495), ATP4B(496)

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相关类别

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

Lansoprazole may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique, kinetic spectrophotometric technique and capillary electrophoresis.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Lansoprazole is an important proton pump inhibitor and a substituted benzimidazole with antisecretory and antiulcer activities. Its mode of action involves the suppression of gastric acid secretion by specific inhibition of the gastric H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cells.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3483 in the slot below. This is an example certificate only and may not be the lot that you receive.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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A kinetic spectrophotometric method for the determination of lansoprazole in pharmaceutical formulations
Rahman N, et al.
J. Serb. Chem. Soc., 71(10) (2006)
The determination of lansoprazole in pharmaceutical preparation by capillary electrophoresis
Dongrukol-Ak D, et al.
Chromatographia, 54(7-8), 527-530 (2001)
Simultaneous spectrophotometric determination of lansoprazole and domperidone in capsule dosage form
Sherje PA, et al.
Indian Journal of Pharmaceutical Sciences, 70(1), 102-102 (2008)

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