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Merck
CN

PHR1524

Supelco

坦洛新

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

盐酸坦洛新 盐酸盐

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About This Item

经验公式(希尔记法):
C20H28N2O5S · HCl
分子量:
444.97
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to BP 876
traceable to Ph. Eur. Y0000650
traceable to USP 1643260

API类

tamsulosin

CofA

current certificate can be downloaded

包装

ampule of 1 × 200 mg

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

储存温度

-10 to -25°C

SMILES字符串

Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(N)(=O)=O

InChI

1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1

InChI key

ZZIZZTHXZRDOFM-XFULWGLBSA-N

基因信息

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一般描述

Tamsulosin hydrochloride is a subtypeselective a1A and a1D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.

应用

Tamsulosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.

附注

To see an example of a Certificate of Analysis for this material enter LRAC0288 in the slot below. This is an example certificate only and may not be the lot that you receive.

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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访问文档库

Validated stability indicating HPTLC method for the determination of Tamsulosin hydrochloride in pharmaceutical dosage forms
Choudhari.PV and Nikalje GPA
International Journal of ChemTech Research, 2(1), 646-652 (2010)
Development and validation of stability-indicating HPTLC determination of tamsulosin in bulk and pharmaceutical dosage form
Bari.BS, et al.
Chromatography Research International, 2011(2), 197-205 (2011)
Validated RP-HPLC and TLC methods for simultaneous estimation of tamsulosin hydrochloride and finasteride in combined dosage forms
Patel B.D and Patel J.N
Acta pharmaceutica, 60(2), 197-205 (2010)

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