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Merck
CN

PHR1585

埃索美拉唑镁

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

(S)-奥美拉唑镁 三水合物

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关于此项目

经验公式（希尔记法）:
C34H36MgN6O6S2 · 3H2O
化学文摘社编号:
217087-09-7
分子量:
767.17
UNSPSC Code:
41116107
NACRES:
NA.24

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产品名称

埃索美拉唑镁, Pharmaceutical Secondary Standard; Certified Reference Material

SMILES string

[Mg+2].[S](=O)(Cc6ncc(c(c6C)OC)C)c4[n-]c5c(n4)cc(cc5)OC.[S](=O)(Cc3ncc(c(c3C)OC)C)c1[n-]c2c(n1)cc(cc2)OC.O.O.O

InChI

1S/2C17H18N3O3S.Mg.3H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;;;/h2*5-8H,9H2,1-4H3;;3*1H2/q2*-1;+2;;;

InChI key

VEVZQDGATGBLIC-UHFFFAOYSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001028
traceable to USP 1249789

API family

omeprazole

CofA

current certificate can be downloaded

packaging

ampule of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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相关类别

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Esomeprazole Magnesium may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using UV-Vis spectroscopy technique and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Esomeprazole Magnesium is theS-isomer of omeprazole and is widely used for the treatment of acid related diseases. It is the first single optical isomer proton pump inhibitor and is found to be better over omeprazole in terms of pharmacokinetic characteristics and acid suppression.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC1677 in the slot below. This is an example certificate only and may not be the lot that you receive.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Development and validation of analytical methods for Simultaneous estimation of domperidone and esomeprazole Magnesium in bulk and in pharmaceutical formulations Using UV-Visible spectroscopy
BPD, et al.
Development, 6(5), 1501-1508 (2014)
Spectrophotometric Determination of Esomeprazole Magnesium in Commercial Tablets Using 5?Sulfosalicylic Acid and N?Bromosuccinimide
Rahman N, et al.
J. Chin. Chem. Soc., 55(3), 557-566 (2008)

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