PHR1589
17-醋酸甲羟孕酮
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
17α-乙酰氧基-6α-甲基孕酮, 17α-羟基-6α-甲基-4-孕烯-3,20-二酮 17-乙酸酯, 6α-甲基-17α-羟基孕酮乙酸酯, 6α-甲基-17α-羟孕酮醋酸酯
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关于此项目
经验公式（希尔记法）:
C24H34O4
化学文摘社编号:
分子量:
386.52
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-757-9
Beilstein/REAXYS Number:
2066112
MDL number:
InChI key
PSGAAPLEWMOORI-PEINSRQWSA-N
InChI
1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
SMILES string
[H][C@@]12C[C@H](C)C3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(OC(C)=O)C(C)=O
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. M0250000, traceable to USP 1378001
API family
medroxyprogesterone
CofA
current certificate can be downloaded
packaging
ampule of 500 mg
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
206-207 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... PGR(5241)
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General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Medroxyprogesterone acetate is a synthetic progestational drug utilized as a contraceptive. It is also used as a medication for the treatment of hormone-dependent cancers, such as breast cancer.
Application
Medroxyprogesterone Acetate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical suspensions, bulk drug and tablet formulations by Raman spectroscopy and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Analysis Note
These secondary standards offer multi-traceability to the USP and EPprimary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2690 in the slot below. This is an example certificate only and may not be the lot that you receive.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 4 - Carc. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
涉药品监管产品
此项目有
Development and validation of a reversed-phase liquid chromatographic method for analysis of estradiol valerate and medroxyprogesterone acetate in a tablet formulation
Segall A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 19(5), 803-808 (1999)
Raman spectroscopic method for the determination of medroxyprogesterone acetate in a pharmaceutical suspension: validation of quantifying abilities, uncertainty assessment and comparison with the high performance liquid chromatography reference method
De Beer TRM, et al.
Analytica Chimica Acta, 589(2), 192-199 (2007)
Simultaneous determination of estradiol valerate and medroxyprogesterone acetate in a tablet formulation by gas chromatography-mass spectrometry
Yilmaz B
Analytical Sciences, 26(3), 391-393 (2010)
Medroxyprogesterone Acetate
USP42-NF37
United States Pharmacopeia/National Formulary, 29(5), 2707-2707 (2013)
A stability-indicating HPLC method for medroxyprogesterone acetate in bulk drug and injection formulation
Burana-osot J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(5), 1068-1072 (2006)
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