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Merck
CN

PHR1598

盐酸普拉克索

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Pramipexole dihydrochloride monohydrate, (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino) benzothiazole dihydrochloride

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关于此项目

经验公式（希尔记法）:
C10H17N3S · 2HCl · H2O
化学文摘社编号:
191217-81-9
分子量:
302.26
UNSPSC Code:
41116107
NACRES:
NA.24

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产品名称

盐酸普拉克索, Pharmaceutical Secondary Standard; Certified Reference Material

SMILES string

[s]1c2c(nc1N)CC[C@@H](C2)NCCC.[Cl-].[Cl-].O.[H+].[H+]

InChI

1S/C10H17N3S.2ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H;1H2/t7-;;;/m0.../s1

InChI key

APVQOOKHDZVJEX-QTPLPEIMSA-N

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001266
traceable to USP 1553859

API family

pramipexole

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Pramipexole Dihydrochloride may be used as a secondary pharma standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA4714 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H336

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

target_organs

Central nervous system

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Ecofriendly spectrophotometric method development and their validation for quantitative estimation of Pramipexole Dihyrochloride using mixed hydrotropic agent
Jain N, et al.
Journal of Chemical and Pharmaceutical Research , 3(1), 548-552 (2009)
Spectrophotometric methods for the estimation of pramipexole dihydrochloride in pharmaceutical formulations
Gurupadayya MB, et al.
World Journal of chemistry, 4(2), 157-160 (2009)

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