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经验公式(希尔记法):
C19H27N5O4 · HCl
化学文摘社编号:
分子量:
425.91
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
盐酸阿夫唑嗪 盐酸盐, Pharmaceutical Secondary Standard; Certified Reference Material
InChI
1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H
SMILES string
Cl.COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3
InChI key
YTNKWDJILNVLGX-UHFFFAOYSA-N
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. A0325800
traceable to USP 1012917
API family
alfuzosin
CofA
current certificate can be downloaded
packaging
ampule of 1 × 1 g
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
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Application
Alfuzosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of alfuzosin hydrochloride levels in pharmaceutical formulations by reverse phase high-performance liquid chromatography (RP-HPLC), high performance thin layer chromatography (HPTLC) and spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
Alfuzosin hydrochloride is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia (BPH). It works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate.
Alfuzosin hydrochloride is an alpha-adrenergic blocker.
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
To see an example of a Certificate of Analysis for this material enter LRAA5304 in the slot below. This is an example certificate only and may not be the lot that you receive.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Development of new spectrophotometric methods for the determination of Alfuzosin hydrochloride in bulk and pharmaceutical formulations
Kumar DR, et al.
Orient. J. Chem., 24(2), 725-728 (2008)
Spectrophotometric determination of alfuzosin HCl in pharmaceutical formulations with some sulphonephthalein dyes
Ashour S, et al.
International Journal of Biomedical Science : IJBS, 2(3), 273-278 (2006)
Validated HPLC and HPTLC stability-indicating methods for determination of alfuzosin hydrochloride in bulk powder and pharmaceutical formulations
Salah FA, et al.
Journal of Separation Science, 29(18), 2716-2724 (2006)
Development and validation of reverse phase high performance liquid chromatography and high performance thin layer chromatography methods for estimation of alfuzosin hydrochloride in bulk and in pharmaceutical formulations
Patel DB and Patel NJ
International Journal of ChemTech Research, 1(4), 985-990 (2009)
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