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Merck
CN

PHR1664

利福霉素 SV 钠盐

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Rifamycin SV sodium salt

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关于此项目

经验公式（希尔记法）:
C37H46NNaO12
化学文摘社编号:
14897-39-3
分子量:
719.75
NACRES:
NA.24
UNSPSC Code:
41116107
EC Number:
238-965-7

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产品名称

利福霉素 SV 钠盐, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

YVOFSHPIJOYKSH-NLYBMVFSSA-M

InChI

1S/C37H47NO12.Na/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41;/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46);/q;+1/p-1/b11-10+,14-13+,17-12-;/t16-,18+,19+,20+,25-,29-,30+,33+,37-;/m0./s1

SMILES string

[Na+].CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)cc([O-])c4c3C2=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. R1000000

API family

rifampicin, rifamycin

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

Quality Level

300

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相关类别

Other Notes

To see an example of a Certificate of Analysis for this material enter LRAA6000 in the slot below. This is an example certificate only and may not be the lot that you receive.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Rifamycin Sodium may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using manual and semiautomatic kinetic method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Rifamycin Sodium is a simplest rifamycin obtained via the elimination of glycolic moity from rifamycin B. It belongs to the ansamicin group of antibiotics. Rifamycin sodium is widely used in surgery and for the treatment of synovitis by intracellular injections.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Antibiotic and chemotherapy e-book (2010)
Kinetic determination of ansamicins in pharmaceutical formulations and human urine. Manual and semiautomatic (stopped-flow) procedures
Espinosa-Mansilla A, et al.
Analytica Chimica Acta, 376(3), 365-375 (1998)

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