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Merck
CN

PHR1666

乙醚

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

二乙醚, 乙醚, 醚

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线性分子式:
(CH3CH2)2O
化学文摘社编号:
分子量:
74.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-467-2
Beilstein/REAXYS Number:
1696894
MDL number:
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InChI key

RTZKZFJDLAIYFH-UHFFFAOYSA-N

InChI

1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3

SMILES string

CCOCC

grade

certified reference material, pharmaceutical secondary standard

vapor density

2.6 (vs air)

CofA

current certificate can be downloaded

autoignition temp.

320 °F

quality

pharmaceutical secondary standard

expl. lim.

36.5 %

packaging

pkg of 3 × 1.2 mL

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.3530 (lit.)

Quality Level

mp

−116 °C (lit.)

density

0.706 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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General description

Diethyl ether is a non-polar volatile organic solvent, commonly used as an extraction solvent in liquid-liquid extraction for separation of post reaction residues from synthetic products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Diethyl ether may be used as a solvent reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0145 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 1 - STOT SE 3

target_organs

Central nervous system

supp_hazards

存储类别

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-40.0 °F - closed cup

flash_point_c

-40 °C - closed cup

法规信息

监管及禁止进口产品
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Determination of residual solvent levels in bulk pharmaceuticals by capillary gas chromatography
Smith ID and Waters DG
Analyst, 116(12), 1327-1331 (1991)
Residual solvent testing: a review of gas-chromatographic and alternative techniques
B'Hymer C
Pharmaceutical Research, 20(3), 337-344 (2003)
Organic solvents in the pharmaceutical industry
Grodowska K and Parczewski A
Acta Poloniae Pharmaceutica, 67(1), 3-12 (2010)

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