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PHR1705

盐酸甲氟喹

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

甲氟喹 盐酸盐, (AS)-rel-a-(2R)-2-哌啶基-2,8-双(三氟甲基)-4-喹啉甲醇单盐酸盐

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关于此项目

经验公式（希尔记法）:
C17H17ClF6N2O
化学文摘社编号:
51773-92-3
分子量:
414.77
NACRES:
NA.24
PubChem Substance ID:
329823568
UNSPSC Code:
41116107
EC Number:
257-412-0
MDL number:
MFCD00797519

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产品名称

盐酸甲氟喹, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

WESWYMRNZNDGBX-YLCXCWDSSA-N

InChI

1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1

SMILES string

Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. M0253000
traceable to USP 1379059

API family

mefloquine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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相关类别

Biochem/physiol Actions

间隙连接通道Cx36和Cx50的阻断剂。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Mefloquine Hydrochloride may be used as a pharmaceutical reference standard for the determination of mefloquine in pharmaceutical formulations and plasma samples by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3945 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Development and validation of a reversed-phase LC method for analysing potentially counterfeit antimalarial medicines.
Gaudiano MC, et al.
Journal of Pharmaceutical and Biomedical Analysis, 42(1), 132-135 (2006)
Screening study of SFC critical method parameters for the determination of pharmaceutical compounds.
Dispas A, et al.
Journal of Pharmaceutical and Biomedical Analysis, 125(31), 339-354 (2016)
Development of a generic micellar electrokinetic chromatography method for the separation of 15 antimalarial drugs as a tool to detect medicine counterfeiting.
Lamalle C, et al.
Electrophoresis, 33(11), 1669-1678 (2012)
Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space.
Debrus B, et al.
Journal of Chromatography A, 1218(31), 5205-5215 (2011)
An analytical method with a single extraction procedure and two separate high performance liquid chromatographic systems for the determination of artesunate, dihydroartemisinin and mefloquine in human plasma for application in clinical pharmacological studies of the drug combination.
Lai CS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 857(2), 308-314 (2007)

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