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Merck
CN

PHR1710

盐酸西替利嗪相关化合物A

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Cetirizine ethyl ester dihydrochloride, (RS)-2-[2-[4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic acid ethyl ester dihydrochloride (Cetirizine hydrochloride Related Compound A), (RS)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic acid ethyl ester dihydrochloride

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关于此项目

经验公式（希尔记法）:
C23H29ClN2O3 · 2HCl
化学文摘社编号:
246870-46-2
分子量:
489.86
UNSPSC Code:
41116107
EC Number:
206-137-4
NACRES:
NA.24

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产品名称

盐酸西替利嗪相关化合物A, Pharmaceutical Secondary Standard; Certified Reference Material

SMILES string

Clc1ccc(cc1)C(N3CCN(CC3)CCOCC(=O)OCC)c2ccccc2

InChI key

ASHQTVRYHSZGQY-UHFFFAOYSA-N

InChI

1S/C23H29ClN2O3/c1-2-29-22(27)18-28-17-16-25-12-14-26(15-13-25)23(19-6-4-3-5-7-19)20-8-10-21(24)11-9-20/h3-11,23H,2,12-18H2,1H3

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1102930

API family

cetirizine

CofA

current certificate can be downloaded

packaging

pkg of 40 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

Quality Level

300

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Cetirizine hydrochloride has been used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry and chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Cetirizine hydrochloride Related Compound A is an impurity of cetirizine hydrochloride. Cetirizine hydrochloride is a second-generation antihistamine compound. It is a major metabolite of hydroxyzine that exhibits high specific affinity for histamine H1 receptor. It is used for the management of allergies, hay fever, angioedema, and urticaria.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7298 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Simultaneous quantitation and validation of paracetamol, phenylpropanolamine hydrochloride and cetirizine hydrochloride by RP-HPLC in bulk drug and formulation
Suryan AL, et al.
International Journal of Pharmaceutical Sciences and Drug Research, 3(4), 303-308 (2011)
Development and Validation of RP-HPLC Method for Simultaneous Estimation of Cetirizine Hydrochloride and Phenylpropanolamine Hydrochloride in Tablet Dosage Form.
Dhongle PS, et al.
Research Journal of Pharmacy and Technology, 4(9), 1471-1474 (2011)
Determination and quantification of cetirizine HCl in dosage formulations by RP-HPLC
Wankhede SB, et al.
International Journal of Pharmaceutical Sciences and Drug Research, 4(3), 222-226 (2012)
RP-HPLC and spectrophotometric estimation of ambroxol hydrochloride and cetirizine hydrochloride in combined dosage form.
Bhatia NM, et al.
Indian Journal of Pharmaceutical Sciences, 70(5), 603-603 (2008)
Determination and quantification of cetirizine HCl in dosage formulations by RP-HPLC.
ARAYNE MS, et al.
Science, 1(4), 1-4 (2005)

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