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Merck
CN

PHR1955

盐酸甲哌卡因

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

Mepivacaine hydrochloride, 1-Methyl-2′,6′-pipecoloxylidine hydrochloride, N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride

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关于此项目

经验公式（希尔记法）:
C15H22N2O · HCl
化学文摘社编号:
1722-62-9
分子量:
282.81
UNSPSC Code:
41116107
NACRES:
NA.24
EC Number:
217-023-9
MDL number:
MFCD00144738

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产品名称

盐酸甲哌卡因, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

RETIMRUQNCDCQB-UHFFFAOYSA-N

InChI

1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H

SMILES string

CN1CCCCC1C(NC2=C(C)C=CC=C2C)=O.Cl

grade

certified reference material
pharmaceutical secondary standard

agency

USP 1387002
traceable to Ph. Eur. M0370000

API family

mepivacaine

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

application(s)

pharmaceutical

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Mepivacaine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current.
Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mepivacaine hydrochloride is a local anesthetic that is related chemically and pharmacologically to the amide-type local anesthetics. It is often administered via local infiltration, peripheral nerve block, etc.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB1955 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H336

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

target_organs

Central nervous system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Mepivacaine hydrochloride
USP42-NF37
United States Pharmacopeia/National Formulary, 38(6), 2743-2743 (2018)
The Estimation of Mepivacain Hydrochloride Injection Liquid
Hazarathaiah C
International Journal of Engineering and Techniques null
Determination of local anaesthetics and their impurities in pharmaceutical preparations using HPLC method with amperometric detection
Fijalek Z, et al.
Journal of Pharmaceutical and Biomedical Analysis, 37(5), 913-918 (2005)

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