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A155

反式-(±)-ACPD 一水合物

Name: <I>反式</I>-(±)-ACPD 一水合物
Brand: SIGMA

solid, ≥97% (NMR)

别名:

trans-(±)-1-Amino-1,3-cyclopentanedicarboxylic acid monohydrate

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关于此项目

经验公式（希尔记法）:

C₇H₁₁NO₄ · H₂O

化学文摘社编号:

67684-64-4

分子量:

191.18

NACRES:

NA.32

PubChem Substance ID:

24277952

UNSPSC Code:

12352200

MDL number:

MFCD11046039

Assay:

≥97% (NMR)

Form:

solid

Quality level:

100

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Quality Level

100

assay

≥97% (NMR)

form

solid

color

white

solubility

H₂O: 1 mg/mL

SMILES string

O.N[C@]1(CC[C@H](C1)C(O)=O)C(O)=O

InChI

1S/C7H11NO4.H2O/c8-7(6(11)12)2-1-4(3-7)5(9)10;/h4H,1-3,8H2,(H,9,10)(H,11,12);1H2/t4-,7+;/m1./s1

InChI key

AZRMVYVZWAKHMR-RERZVJIGSA-N

Gene Information

human ... GRM1(2911), GRM2(2912), GRM3(2913), GRM4(2914), GRM5(2915), GRM6(2916), GRM7(2917), GRM8(2918)

Biochem/physiol Actions

Excitatory amino acid receptor agonist; selective for the metabotropic glutamate receptor subtype.

Other Notes

Note: under IUPAC nomenclature, this compound is designated cis.

pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332

pcodes

P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ.

Tzu-Chieh Chen et al.

Science signaling, 10(489) (2017-07-27)

Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein angiopoietin-like 4, which mediates glucocorticoid-induced lipolysis in white adipose

In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects.

D D Schoepp et al.

Journal of neurochemistry, 56(5), 1789-1796 (1991-05-01)

This study explored further the function of the metabotropic excitatory amino acid receptor in the rat brain. The trans and cis isomers of (+-)-1-amino-1,3-cyclopentane-dicarboxylic acid (ACPD) were characterized for relative affinities at ionotropic and metabotropic excitatory amino acid receptors in

Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor.

E Palmer et al.

European journal of pharmacology, 166(3), 585-587 (1989-08-03)

Tone-dependent vascular responses to astrocyte-derived signals.

Víctor M Blanco et al.

American journal of physiology. Heart and circulatory physiology, 294(6), H2855-H2863 (2008-05-06)

A growing number of studies support an important contribution of astrocytes to neurovascular coupling, i.e., the phenomenon by which variations in neuronal activity trigger localized changes in blood flow that serve to match the metabolic demands of neurons. However, since

Autoradiographic imaging of phosphoinositide turnover in the brain.

P M Hwang et al.

Science (New York, N.Y.), 249(4970), 802-804 (1990-08-17)

With [3H]cytidine as a precursor, phosphoinositide turnover can be localized in brain slices by selective autoradiography of the product [3H]cytidine diphosphate diacylglycerol, which is membrane-bound. In the cerebellum, glutamatergic stimulation elicits an increase of phosphoinositide turnover only in Purkinje cells

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全球贸易项目编号

货号	GTIN
A155-5MG	04061833342459
A155-25MG	04061833001851
A155-100MG	04061832281353

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