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Merck
CN

BP1210

利托那韦

British Pharmacopoeia (BP) Reference Standard

别名:

1,3-噻唑-5-基甲基 N-[（2S,3S,5S）-3-羟基-5-[[（2S）-3-甲基-2-[[甲基-[（2-丙-2-基-1,3-噻唑-4-基）甲基]氨基甲酰基]氨基]丁酰基]氨基]-1,6-二苯基己基-2-基]氨基甲酸酯

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关于此项目

经验公式（希尔记法）:
C37H48N6O5S2
化学文摘社编号:
155213-67-5
分子量:
720.94
MDL number:
MFCD08694944
UNSPSC Code:
41116107
NACRES:
NA.24

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产品名称

利托那韦, British Pharmacopoeia (BP) Reference Standard

SMILES string

[s]1c(nc(c1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@@H](NC(=O)OCc4[s]cnc4)Cc3ccccc3)Cc2ccccc2)C(C)C

InChI

1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

InChI key

NCDNCNXCDXHOMX-XGKFQTDJSA-N

grade

pharmaceutical primary standard

agency

BP

API family

ritonavir

form

solid

shelf life

limited shelf life, expiry date on the label

packaging

pkg of 100 mg

manufacturer/tradename

BP

storage condition

dry at room temperature

color

off-white

mp

122-126  °C

solubility

ethanol: soluble
isopropanol: soluble
methanol: soluble

density

1.239 g/cm3 at 20 °C

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

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相关类别

Application

Ritonavir BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Ritonavir Oral Solution
  • Ritonavir Tablets

    • General description

    Ritonavir belongs to the group of protease inhibitors that are widely used in combination with other drugs in the prevention of HIV. Its mode of action involves binding to the active site of the protease enzyme and preventing the further maturation of new viral particles.
    This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

    Other Notes

    Sales restrictions may apply.

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    pictograms

    Exclamation mark
    GHS07

    signalword

    Warning

    Hazard Classifications

    Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

    存储类别

    11 - Combustible Solids

    wgk

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

    历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number

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    RP-HPLC method development and validation for simultaneous estimation of Lopinavir and Ritonavir in tablet dosage form
    Bindu MJ, et al.
    International Journal of Science and Engineering Applications, 5(1), 77-77 (2017)
    HPTLC method for simultaneous determination of lopinavir and ritonavir in capsule dosage form
    Sulebhavikar VA, et al.
    Journal of Chemistry, 5(4), 706-712 (2008)

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