1535008
USP
苯妥英
United States Pharmacopeia (USP) Reference Standard
别名:
5,5-二苯基海因, 5,5-联苯基乙内酰脲, 苯妥英
等级
pharmaceutical primary standard
API类
phenytoin
制造商/商品名称
USP
mp
293-295 °C (lit.)
应用
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
InChI
1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
InChI key
CXOFVDLJLONNDW-UHFFFAOYSA-N
基因信息
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Phenytoin USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Phenytoin Sodium
- Phenytoin Chewable Tablets
- Phenytoin Oral Suspension
- Phenytoin Sodium Injection
- Extended Phenytoin Sodium Capsules
- Phenytoin Compounded Topical Gel
- Fosphenytoin Sodium Injection
生化/生理作用
减少癫痫大发作的发生率；可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。
抗惊厥剂。
分析说明
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
免责声明
Sales restrictions may apply.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Carc. 2 - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Deborah Pugin et al.
Critical care (London, England), 18(3), R103-R103 (2014-06-03)
Seizures refractory to third-line therapy are also labeled super-refractory status epilepticus (SRSE). These seizures are extremely difficult to control and associated with poor outcome. We aimed to characterize efficacy and side-effects of continuous infusions of pentobarbital (cIV-PTB) treating SRSE. We
H Kamp et al.
Bioanalysis, 4(18), 2291-2301 (2012-10-11)
BASF and Metanomics have built-up the database MetaMap(®)-Tox containing rat plasma metabolome data for more than 500 reference compounds. Phenytoin was administered to five Wistar rats of both sexes at dietary dose levels of 600 and 2400 ppm over 28
Anthony Foianini et al.
Clinical toxicology (Philadelphia, Pa.), 48(4), 325-330 (2010-05-29)
Tricyclic antidepressant (TCA) poisoning is a relatively common occurrence and remains a significant cause of mortality and morbidity. Deaths from TCA toxicity are typically due to cardiovascular events such as arrhythmias and hypotension. Cardiovascular toxicity may be multifactorial. However, the
Precision, bias, and clinical utility of the Sheiner-Tozer equation to guide phenytoin dosing in critically ill adults.
Jennifer Bolt et al.
Journal of clinical pharmacology, 53(4), 451-455 (2013-02-26)
Anoop S V Shah et al.
Clinical toxicology (Philadelphia, Pa.), 48(8), 800-805 (2010-10-07)
Seizures are a common sequela of self-poisoning. However, their mechanism differs from seizures of other etiologies. Toxicological seizures result from alterations in the excitatory and inhibitory balance of otherwise normal neurons. In contrast, idiopathic or trauma related seizures usually start
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