- Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
Organic & biomolecular chemistry (2012-11-08)
Rania M Deranieh, Miriam L Greenberg, Pierre-B Le Calvez, Maura C Mooney, Marie E Migaud
PMID23132282
摘要
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.
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Sigma-Aldrich
D -山梨醇, ≥98% (GC), BioReagent, suitable for cell culture, suitable for plant cell culture
山梨醇, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
山梨醇 F 液 溶液, 70 wt. % in H2O, Contains mainly D-sorbitol with lesser amounts of other hydrogenated oligosaccharides