Donepezil suppresses intracellular Ca

Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer's disease (AD) is related to the inflammatory responses mediated by microglia. Intracellular Ca We examined whether pretreatment with donepezil affects the intracellular Ca In this study, we observed that pretreatment with donepezil suppressed the TNFα-induced sustained intracellular Ca These suggest that donepezil could directly modulate the microglial function through the PI3K pathway in the rodent brain, which might be important to understand the effect of donepezil in the brain.