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Merck
CN

900859

3-Bromo-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

Synonym(s):

Bromo sulfonyl fluoride TMS-alkyne, Probe building block

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About This Item

Empirical Formula (Hill Notation):
C11H12BrFO2SSi
CAS Number:
2088829-15-4
Molecular Weight:
335.26
MDL number:
MFCD31579818
UNSPSC Code:
12352200
NACRES:
NA.22
Assay:
≥95%
Form:
powder or crystals

Key Documents

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Product Name

3-Bromo-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%

InChI key

CUUVPHAGWQDSCZ-UHFFFAOYSA-N

InChI

1S/C11H12BrFO2SSi/c1-17(2,3)5-4-9-6-10(12)8-11(7-9)16(13,14)15/h6-8H,1-3H3

SMILES string

[Si](C)(C)(C)C#Cc1cc(cc(c1)Br)[S](=O)(=O)F

assay

≥95%

form

powder or crystals

reaction suitability

reaction type: click chemistry

storage temp.

−20°C

Quality Level

100

Related Categories

Application

3-Bromo-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

Technology Spotlight: Trifunctional Probe Building Blocks

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Articles

Trifunctional Probe Building Blocks

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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