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Merck
CN

900865

4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

Synonym(s):

Formyl sulfonyl fluoride TMS-Alkyne, Probe building block

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About This Item

Empirical Formula (Hill Notation):
C12H13FO3SSi
CAS Number:
2088829-01-8
Molecular Weight:
284.38
UNSPSC Code:
12352200
NACRES:
NA.22

Key Documents

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Product Name

4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride, ≥95%

SMILES string

O=CC1=CC=C(S(=O)(F)=O)C(C#C[Si](C)(C)C)=C1

assay

≥95%

form

powder or crystals

reaction suitability

reaction type: click chemistry

storage temp.

−20°C

Application

4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and aldehyde synthetic handle. When appended to a ligand or pharmacophore through its formyl linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

Technology Spotlight: Trifunctional Probe Building Blocks

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Articles

SuFEx: Sulfonyl Fluorides that Participate in the Next Click Reaction

In collaboration with K. Barry Sharpless and coworkers, we offer a variety of sulfonyl fluoride reagents that undergo a “Click II” reaction.

Trifunctional Probe Building Blocks

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.

SuFEx：参与下一步点击反应的磺酰氟

在与K. Barry Sharpless及其同事合作后，Sigma-Aldrich现可提供各种磺酰氟试剂，这些试剂经历了“Click II”反应。

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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