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Merck
CN

PHR1606

Supelco

醋酸氢化可的松

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

11β,17α,21-三羟基-4-孕烯-3,20-二酮 21-乙酸酯, 17-α-羟基皮质甾酮乙酸酯, 17-羟基皮质甾酮 21-乙酸酯, 21-乙酰氧基-4-孕烯-11β,17α-二醇-3,20-二酮, 4-孕烯-11β,17α,21-三醇-3,20-二酮 21-乙酸酯

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关于此项目

经验公式（希尔记法）:
C23H32O6
CAS Number:
50-03-3
分子量:
404.50
Beilstein:
2066841
EC 号:
200-004-4
MDL编号:
MFCD00037714
UNSPSC代码:
41116107
PubChem化学物质编号:
329823503
NACRES:
NA.24

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等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. H1400000
traceable to USP 1317007

API类

hydrocortisone

CofA

current certificate can be downloaded

包装

pkg of 1 g

技术

HPLC: suitable
gas chromatography (GC): suitable

mp

223 °C (dec.) (lit.)

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-30°C

SMILES字符串

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

基因信息

human ... NR3C1(2908)

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相关类别

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydrocortisone Acetate belongs to the class of corticosteroids, exhibiting antipruritic, anti-inflammatory and vasoconstrictive properties. It is used in the treatment of various conditions such as allergic and breathing disorders or skin conditions.

应用

Hydrocortisone Acetate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography and thin layer chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析说明

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3177 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360Df,H373

危险分类

Repr. 1B - STOT RE 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

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Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC
Hajkova R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 32(4), 921-927 (2003)
Validation of a thin-layer chromatography for the determination of hydrocortisone acetate and lidocaine in a pharmaceutical preparation
Dolowry M, et al.
TheScientificWorldJournal, 32(4), 921-927 (2014)
Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC.
Hajkova R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 921-927 (2003)

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