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文件

Y0001167

苯妥英钠

Name: 苯妥英钠
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

5,5-二苯基海因, 5,5-联苯基乙内酰脲, 苯妥英

经验公式（希尔记法）:

C₁₅H₁₂N₂O₂

CAS号:

57-41-0

分子量:

252.27

Beilstein:

384532

MDL编号:

MFCD00005264

PubChem化学物质编号:

329831289

NACRES:

NA.24

等级

pharmaceutical primary standard

API类

phenytoin

制造商/商品名称

EDQM

mp

293-295 °C (lit.)

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

SMILES字符串

O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3

InChI

1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)

InChI key

CXOFVDLJLONNDW-UHFFFAOYSA-N

基因信息

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Phenytoin for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

减少癫痫大发作的发生率；可能通过 Na⁺、K⁺ 和 Ca²⁺ 通道的影响而稳定可兴奋膜。

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

PHR1574

PHR1692

BP1238

5,5-二苯基海因钠盐, British Pharmacopoeia (BP) Reference Standard

PHR2246

苯妥英中间化合物M01, Pharmaceutical Secondary Standard; Certified Reference Material

PHR9055

苯偶酰, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2247

5-(4-Methylphenyl)hydantoin

PHR2553

Phenytoin Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

象形图

GHS07,GHS08

警示用语：

Danger

危险声明

H302 - H351 - H360FD

预防措施声明

P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313

危险分类

Acute Tox. 4 Oral - Carc. 2 - Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors.

Adam S Wu et al.

Journal of neurosurgery, 118(4), 873-883 (2013-02-12)

Seizures are a potentially devastating complication of resection of brain tumors. Consequently, many neurosurgeons administer prophylactic antiepileptic drugs (AEDs) in the perioperative period. However, it is currently unclear whether perioperative AEDs should be routinely administered to patients with brain tumors

Is pentobarbital safe and efficacious in the treatment of super-refractory status epilepticus: a cohort study.

Deborah Pugin et al.

Critical care (London, England), 18(3), R103-R103 (2014-06-03)

Seizures refractory to third-line therapy are also labeled super-refractory status epilepticus (SRSE). These seizures are extremely difficult to control and associated with poor outcome. We aimed to characterize efficacy and side-effects of continuous infusions of pentobarbital (cIV-PTB) treating SRSE. We

Association between use of antiepileptic drugs and fracture risk: a systematic review and meta-analysis.

Chunhong Shen et al.

Bone, 64, 246-253 (2014-05-02)

It has been shown that antiepileptic drugs (AEDs) may have a detrimental effect on bone health and translate into an increased risk of bone fracture. We aimed to comprehensively evaluate the association between use of AEDs and fracture risk. We

Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study.

Kimford J Meador et al.

The Lancet. Neurology, 12(3), 244-252 (2013-01-29)

Many women of childbearing potential take antiepileptic drugs, but the cognitive effects of fetal exposure are uncertain. We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up to 6 years of age. In this

Magnesium sulphate versus phenytoin for eclampsia.

Lelia Duley et al.

The Cochrane database of systematic reviews, (10)(10), CD000128-CD000128 (2010-10-12)

Eclampsia, the occurrence of a seizure in association with pre-eclampsia, remains a rare but serious complication of pregnancy. A number of different anticonvulsants have been used to control eclamptic fits and to prevent further seizures. The objective of this review

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