跳转至内容

CN

The lifespan-promoting effect of acetic acid and Reishi polysaccharide.

The lifespan-promoting effect of acetic acid and Reishi polysaccharide.

Bioorganic & medicinal chemistry (2009-10-20)

Ming-Hong Chuang, Shyh-Horng Chiou, Chun-Hao Huang, Wen-Bin Yang, Chi-Huey Wong

摘要

Using Caenorhabditis elegans as a model organism, various natural substances and commercial health-food supplements were screened to evaluate their effects on longevity. Among the substances tested, acetic acid and Reishi polysaccharide fraction 3 (RF3) were shown to increase the expression of the lifespan and longevity-related transcription factor DAF-16 in C. elegans. We have shown that RF3 activates DAF-16 expression via TIR-1 receptor and MAPK pathway whereas acetic acid inhibits the trans-membrane receptor DAF-2 of the insulin/IGF-1 pathway to indirectly activate DAF-16 expression. In addition, a mixture of acetic acid and RF3 possesses a combined effect 30-40% greater than either substance used alone. A proteomic analysis of C. elegans using 2-DE and LC-MS/MS was then carried out, and 15 differentially expressed proteins involved in the lifespan-promoting activity were identified.

材料

产品编号

品牌

产品描述

Sigma-Aldrich

乙酸, glacial, ACS reagent, ≥99.7%

Sigma-Aldrich

乙酸, glacial, ReagentPlus^®, ≥99%

Sigma-Aldrich

无水柠檬酸粉末, meets analytical specification of Ph. Eur., BP, USP, E330, anhydrous, 99.5-100.5% (based on anhydrous substance)

Sigma-Aldrich

乙酸, glacial, ≥99.99% trace metals basis

Sigma-Aldrich

乙酸溶液, suitable for HPLC

Sigma-Aldrich

乙酸, glacial, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8%

Sigma-Aldrich

乙酸, glacial, puriss., meets analytical specification of Ph. Eur., BP, USP, 99.8-100.5%

Sigma-Aldrich

无水柠檬酸粉末, ACS reagent, ≥99.5%

Sigma-Aldrich

苯甲酸, ACS reagent, ≥99.5%

Sigma-Aldrich

无水柠檬酸粉末, ≥99.5%, FCC, FG

Sigma-Aldrich

无水柠檬酸粉末, 99%

Sigma-Aldrich

无水柠檬酸粉末, anhydrous, suitable for cell culture, suitable for plant cell culture

Sigma-Aldrich

乙酸, suitable for luminescence, BioUltra, ≥99.5% (GC)

Supelco

Mettler-Toledo 校准物质 ME 18555，苯甲酸, analytical standard, (for the calibration of the melting point system), traceable to primary standards (LGC)

Supelco

Melting point standard 121-123°C, analytical standard

Sigma-Aldrich

无水柠檬酸粉末, BioUltra, anhydrous, ≥99.5% (T)

Supelco

乙酸, analytical standard

Sigma-Aldrich

乙酸, ≥99.5%, FCC, FG

Sigma-Aldrich

乙酸, natural, ≥99.5%, FG

Sigma-Aldrich

苯甲酸, meets analytical specification of Ph. Eur., BP, USP, FCC, E210, 99.5-100.5% (alkalimetric)

Supelco

苯甲酸, reference material for titrimetry, certified by BAM, >99.5%

Sigma-Aldrich

乙酸, glacial, puriss., 99-100%

Sigma-Aldrich

苯甲酸, ≥99.5%, FCC, FG

Sigma-Aldrich

苯甲酸, ReagentPlus^®, 99%

Sigma-Aldrich

苯甲酸, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.9% (alkalimetric)

Supelco

苯甲酸, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Sigma-Aldrich

苯甲酸, natural, ≥99.5%, FCC, FG

Sigma-Aldrich

苯甲酸, purified by sublimation, ≥99%

Millipore

Bifido 选择性添加剂 B, suitable for microbiology