跳转至内容

CN

Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression.

Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression.

FEBS letters (2014-08-15)

Junya Kuroyanagi, Yasuhito Shimada, Beibei Zhang, Michiko Ariyoshi, Noriko Umemoto, Yuhei Nishimura, Toshio Tanaka

摘要

Zinc finger, MYND-type containing 8 (ZMYND8) encodes a receptor for activated C-kinase protein. Here, we report that ZMYND8 promotes angiogenesis in prostate cancer xenografts in zebrafish, as well as tube formation in human umbilical vascular endothelial cell (HUVEC) cultures. Using transcriptome analyses, we found upregulation of ZMYND8 expression in both zebrafish prostate cancer xenografts and prostate cancer samples from patients. In vitro and in vivo ZMYND8 knockdown suppressed angiogenesis, whereas ZMYND8 overexpression enhanced angiogenesis. Notably, ZMYND8 induced vegfa mRNA expression selectively in prostate cancer xenografts. Integrated analysis of human and zebrafish transcriptomes, which identified ZMYND8, might be a powerful strategy to determine also other molecular targets for inhibiting prostate cancer progression.

材料

产品编号

品牌

产品描述

Sigma-Aldrich

二甲基亚砜, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

Sigma-Aldrich

二甲基亚砜, ACS reagent, ≥99.9%

Sigma-Aldrich

二甲基亚砜, Molecular Biology

Sigma-Aldrich

二甲基亚砜, suitable for HPLC, ≥99.7%

Sigma-Aldrich

二甲基亚砜, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

Sigma-Aldrich

二甲基亚砜, ReagentPlus^®, ≥99.5%

Sigma-Aldrich

二甲基亚砜, anhydrous, ≥99.9%

Sigma-Aldrich

二甲基亚砜, ≥99.5% (GC), suitable for plant cell culture

Sigma-Aldrich

二甲基亚砜, puriss. p.a., ACS reagent, ≥99.9% (GC)

Sigma-Aldrich

氯化钠, Molecular Biology, DNase, RNase, and protease, none detected, ≥99% (titration)

Sigma-Aldrich

氯化钠溶液, 5 M in H₂O, BioReagent, Molecular Biology, suitable for cell culture

Sigma-Aldrich

氯化钠, BioXtra, ≥99.5% (AT)

Sigma-Aldrich

氯化钙溶液, BioUltra, Molecular Biology, ~1 M in H₂O

Sigma-Aldrich

氯化钠, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99%

Sigma-Aldrich

氯化钠溶液, 0.9% in water, BioXtra, suitable for cell culture

Sigma-Aldrich

氯化钙, anhydrous, BioReagent, suitable for insect cell culture, suitable for plant cell culture, ≥96.0%

Sigma-Aldrich

二甲基亚砜, BioUltra, Molecular Biology, ≥99.5% (GC)

Sigma-Aldrich

2-苯氧基乙醇, ≥99%

Sigma-Aldrich

氯化钠溶液, 5 M

Sigma-Aldrich

二甲基亚砜, meets EP testing specifications, meets USP testing specifications

Sigma-Aldrich

氯化钠, BioUltra, Molecular Biology, ≥99.5% (AT)

Sigma-Aldrich

氯化钠, meets analytical specification of Ph. Eur., BP, USP, 99.0-100.5%

Supelco

2-苯氧基乙醇, Pharmaceutical Secondary Standard; Certified Reference Material

Sigma-Aldrich

氯化钠溶液, BioUltra, Molecular Biology, ~5 M in H₂O

Sigma-Aldrich

氯化钠, 99.999% trace metals basis

Sigma-Aldrich

氯化钙, powder, 99.99% trace metals basis

Supelco

氯化钠, Pharmaceutical Secondary Standard; Certified Reference Material

Sigma-Aldrich

二甲基亚砜, PCR Reagent

Supelco

氯化钠, reference material for titrimetry, certified by BAM, >99.5%

Sigma-Aldrich

氯化钙