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517312

Sigma-Aldrich

Anti-P-Glycoprotein Mouse mAb (C494)

liquid, clone C494, Calbiochem®

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About This Item

UNSPSC代码:
12352203

生物来源

mouse

质量水平

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

C494, monoclonal

表单

liquid

包含

≤0.1% sodium azide as preservative

种属反应性

human, hamster

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
avoid repeated freeze/thaw cycles

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此商品
SAB4200775517310OP03
antibody form

purified antibody

antibody form

purified from hybridoma cell culture

antibody form

purified antibody

antibody form

purified antibody

species reactivity

human, hamster

species reactivity

hamster, human

species reactivity

rat, hamster, human, mouse

species reactivity

rabbit, monkey, human, mouse, rat

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

clone

C494, monoclonal

clone

F4, monoclonal

clone

C219, monoclonal

clone

PAb421, monoclonal

isotype

IgG2a

isotype

IgG1

isotype

IgG1

isotype

IgG2a

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

一般描述

Purified mouse monoclonal antibody. Recognizes the ~170 kDa MDR1 isoform of P-glycoprotein.
Recognizes the ~170 kDa MDR1 isoform of P-glycoprotein. Does not cross-react with the MDR3 P-glycoprotein.
This Anti-P-Glycoprotein Mouse mAb (C494) is validated for use in Paraffin Sections, FC, Frozen Sections, Immunoblotting, ICC, IP for the detection of P-Glycoprotein.

免疫原

Epitope: gene-specific internal cellular epitope present only on the MDR1 isoform of P-glycoprotein
Hamster and Human
SDS-solubilized plasma membranes of a multidrug resistant (MDR) Chinese hamster ovary (CHO) cell line and a human leukemic cell line

应用

Paraffin Sections (5-10 µg/ml, see comments)

Flow Cytometry (see comments)

Frozen Sections (5-10 µg/ml, see comments)

Immunoblotting (see comments)

Immunocytochemistry (see application references)

Immunoprecipitation (see comments)

包装

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

外形

In PBS, 1% BSA.

重悬

Following initial thaw, aliquot and freeze (-20°C).

分析说明

Positive Control
Cell lines or frozen tissue, such as human liver or colon.

其他说明

Does not cross-react with MDR3 P-glycoprotein. Also reported to work for flow cytometry, immunoblotting, and immunoprecipitation. For immunocytochemistry, frozen or paraffin-embedded material may be used. Permeabilization of the cell membrane is required to expose the epitope recognized by this antibody. Variables associated with assay conditions will dictate the proper working dilutions.
Rao, V.V., et al. 1994. Cancer Res.54, 1536.
Toth, K., et al. 1992. Am. J. Pathol.140, 1009.
Georges, E., et al. 1990. Proc. Natl. Acad. Sci. USA87, 152.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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    Multi-drug resistance (MDR) of cancers to chemotherapy including doxorubicin (DOX) is mediated by several factors. To design an effective therapy for the treatment of chemotherapy-resistant cancers, it is essential to explore the elements responsible for mediating MDR. However, exploring these

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