916846
2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid
95%
别名:
Semi-flexible linker for PROTAC® development
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关于此项目
Assay:
95%
Form:
powder
Quality Level
assay
95%
form
powder
reaction suitability
reagent type: linker
functional group
Boc, carboxylic acid
storage temp.
2-8°C
SMILES string
O=C(N(CC1)CCC1C(C=CC=C2)=C2C(O)=O)OC(C)(C)C
InChI
1S/C17H23NO4/c1-17(2,3)22-16(21)18-10-8-12(9-11-18)13-6-4-5-7-14(13)15(19)20/h4-7,12H,8-11H2,1-3H3,(H,19,20)
InChI key
NPKPUCNATSURJQ-UHFFFAOYSA-N
Application
2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.
Tang H, et al.
Bioorganic & Medicinal Chemistry Letters, 20(20), 6088-6092 (2010)
Base- and Additive-Free Ir-Catalyzed ortho-Iodination of Benzoic Acids: Scope and Mechanistic Investigations
Erbing E, et al.
ACS Catalysis, 8(2), 920-925 (2018)
Visible-light-induced intramolecular sp3 C-H oxidation of 2-alkyl-substituted benzamides for the synthesis of functionalized iminoisobenzofurans..
Wu L, et al.
Chemical Communications (Cambridge, England), 55, 13908-13911 (2019)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 916846-100MG | 04061842601301 |