净化深度过滤器和预处理解决方案
我们的澄清产品组合为生物制药生产商提供了从工艺开发到大规模生产的各种工艺流程中高效去除细胞、细胞碎片和其他不溶性杂质以及清除杂质的灵活性。Millistak+®、Millistak+® HC Pro 和 Clarisolve® Depth 过滤器可用于 Pod 设备。
部分概述
Products

Millistak+® HC Pro 过滤器

Millistak+® 深层过滤器

相关产品资源
- Guide: Clarification Portfolio
Single and multi-use products for the successful development and implementation of robust clarification processes.
- Brochure: Millistak+® Family and Clarisolve®
Discover Millistak+® family and Clarisolve® depth filters at a glance.
- Data Sheet: Millistak+® HC Pro Synthetic Depth Filters
Fully synthetic depth filters for clarification and downstream filtration applications.
- Data Sheet: Millistak+® Pod Carbon Depth Filter Media System
Millistak+® carbon (CR) depth filter media incorporates activated carbon for the removal of color and trace contaminants.
- Data Sheet: Clarification Solutions for Pre-treated Feed Streams
Together, the pDADMAC polymer, and Clarisolve® depth filters provide an effective solution for harvesting high cell density cultures that can be easily incorporated into current clarification platforms.
- Data Sheet: Millistak+® Pod Disposable Depth Filter System
High-Performance Pod Filters are Ideal for Primary and Secondary Clarification in Lab, Pilot and Process-scale Applications.
- Article: pDADMAC Flocculation in Monoclonal Antibody Production Processes – Overcoming Regulatory Challenges with Quality Risk Management
Flocculants, like pDADMAC, remove cell debris during downstream monoclonal antibody production, but their adoption has been difficult due to perceived regulatory concerns.
- Application Note: Scalability Studies for Millistak+® HC and Millistak+® HC Pro Micro 20 Devices
Scale-up and Scale-down Primary and Secondary Clarification with C0HC, D0HC, X0HC, C0SP, D0SP, and X0SP Media Grades.
- Article: Generic Process of Virus-Like Particle (VLP) Based Vaccine Manufacturing
A Virus-Like Particle (VLP) is a biological nanoparticle which consists of the protective protein shell of a virus.
- Guide: Millistak+® Pod Disposable Depth Filter Performance
This is a reference document to provide assistance in evaluating and validating Millistak+® Pod depth filters for clarification applications.
- Application Note: Millistak+® Activated Carbon for mAb Downstream Purification
This document demonstrates that Millistak+® Activated Carbon has the ability to reduce HCP present in Protein A elution pools under various solution conditions.
- Article: Membrane Filtration: Efficient Particle Retention and Bioburden Reduction in Bioprocessing Fluid Streams
Some prefilters reduce bioburden and can be used as a cost-effective alternative to sterilizing filters for bioburden control in bioprocessing.
- Application Note: DADMAC Flocculant Reagent for Use with Clarisolve® Depth Filters
pDADMAC improves the removal of contaminants by driving the charged flocculation of the negatively charged entities.
- User Guide: Pod Depth Filters
This document is a comprehensive guide for users of pod depth filters.
- User Guide: μPod® Filters
This document is a comprehensive guide for users of µPod® Filters.
如何规范两步澄清工艺的流程开发方法,确保开发出稳健、可扩展的单元操作
。pDADMAC用于哺乳动物细胞培养收获物的预处理,利用Clarisolve®深度过滤器改进初级净化;对絮凝饲料进行二次净化。
欢迎参加有关从含有 mAbs 的溶液中有效分离宿主细胞蛋白 (HCP)、抗体片段和低分子量物质的案例研究。
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